A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity

Figure 1 Scheme representing various steps of ulcer pathogenicity and multi-step anti-ulcer action by SRPP (•-); (•) and (-) represents phenolic and polysaccharide portions of SRPP respectively. Swim/Ethanol stress leading to OS (1) and liberation of FR (2). FR upregulated H⁺, K⁺-ATPase (3) and induced oxidative damage to mucosa (4) leading to mucosal damage (5). H pylori may invade on to damaged mucosa and together may cause ulcers (7). SRPP has ability to inhibit steps 1-7 including the growth of H pylori in vitro (6).