Fever as the only manifestation of hypersensitivity reactions associated with oxaliplatin in a patient with colorectal cancer Oxaliplatin-induced hypersensitivity reaction

Table 4 Published cases of hypersensitivity associated with oxaliplatin

Reference	Presenting Features	Premedication	Oxaliplatin dose and serial dilution if used	Duration of therapy
Lydia et al[23]	Diaphoresis, hypotension, nausea, abdominal cramping rash, coryza	D1-prednisone 20 mg Po Q6 h × 4 D2 45 min pre chemo ondansterone 8 mg + dexamethasone 20 mg iv 30 min prior diphenylhydramine 50 mg iv + cemetidine 300 mg iv	140 mg on d 2 dilutions from 1:10000 to 1:1	8 h
Thomas et al[5]	Erythematic, flushing	Dexamethasone 20 mg 6 h and 12 h prior 30 min pre infusion: solumedrol 125 mg iv, diphenylhydramine 50 mg iv, cimetidine 50 mg iv	-	2-4 h
Bhargava et al[22]	Palpitation, flushing, hypotension	Dexamethasone starting 24 h prior 30 min before infusion received dexamethasone, diphenylhydramine, hydrocortisone 100 mg iv	1:10000, 1:1000, 1:100, 1:10 each bag infuse over one hour	6-8 h
Meyer et al[7]		dexamethasone-famotidine and diphenylhydramine	90% of total dose 1:1000, 1:100 and 1:10 dilution over 90 min	6 h
Lim et al[24]	Abdominal distension, heat, pruritis	D 1 diphenylhydramine 50 mg QID 30 min prior to infusion metoclopramide 9 mg, morazepam 2 mg, dexamethasone 5 mg iv	Fixed dose infusion over 24 h with dilute solution (0.15 mg/mL)	24 h
Present case	Fever	-	Refused further oxaliplatin therapy	-