Reversal of hyperglycemia in diabetic rats by portal vein transplantation of islet-like cells generated from bone marrow mesenchymal stem cells

Figure 4 Insulin content and release in response to glucose stimulation of BM-MSCs in different groups. Insulin positive rate of D-MSCs was up to around 19.8% and mean fluorescence intensity was increased by 2.6 folds, which was significantly higher than that of pre-induced BM-MSCs. D-MSCs secreted a small amount of insulin into medium and the insulin was increased by 1.5 folds under the glucose challenge. ^aP < 0.05 vs pre-induced BM-MSCs; ^cP < 0.05 vs HG; ^bP < 0.01 vs other group. N: nicotinamide; E: exendin-4.