Reversal of hyperglycemia in diabetic rats by portal vein transplantation of islet-like cells generated from bone marrow mesenchymal stem cells

Figure 3 Immunofluorescence reveals BM-MSCs differentiated into islet-like cells in vitro. Rat RIN-m5F cells displayed insulin (INS), C-peptide (C-P), glucagons (Gcg), somatostatin (SS), but without islet amyloid polypeptide (IAPP) (A, × 400); Pre-induced BM-MSCs were negative for the above islet hormones staining (B, × 400); D-MSCs showed the staining of INS, C-P, Gcg, SS, IAPP (C, × 400); Some D-MSCs co-expressed INS/Gcg, INS/SS, INS/IAPP (D, × 400).