Low-dose tacrolimus ameliorates liver inflammation and fibrosis in steroid refractory autoimmune hepatitis

Table 1 Grading of the inflammatory activity in chronic hepatitis according to Ishak et al (the maximum possible scoring is 18)

	Score
Portal inflammation
None	0
Mild, some or all portal areas	1
Moderate, some or all portal areas	2
Moderate/severe, all portal areas	3
Severe, all portal areas	4
Periportal or periseptal interface hepatitis (“piecemeal necrosis”)
Absent	0
Mild (focal, few portal areas)	1
Mild/moderate (focal, most portal areas)	2
Moderate (continuous around < 50% of tracts or septa)	3
Severe (continuous around > 50% of tracts or septa)	4
Focal parenchymal necrosis
Absent	0
1 focus or less per visual field of 100 × magnification	1
2-4 foci per 100 × magnification	2
5-10 foci per 100 × magnification	3
More than 10 foci per 100 × magnification	4
Confluent necrosis
Absent	0
Focal confluent necrosis	1
Zone 3 necrosis in some areas	2
Zone 3 necrosis in most areas	3
Zone 3 necrosis and occasional portal-central bridging	4
Zone 3 necrosis and multiple portal-central bridging	5
Panacinar or multiacinar necrosis	6