Genotype phenotype classification of hepatocellular adenoma

Figure 1 HNF1α-mutated adenomas (from different cases). A: left: single, yellowish HCA; right: a massive form involving the whole right lobe made of several numerous adjacent nodules of different sizes; B: typical aspect of a steatotic HCA (ad) with a lobulated contour. Inset: HCA at a higher magnification showing macro and microvesicular steatosis (HE); C: left: part of a large focal nodular hyperplasia (indication of surgery), nearby small adenomas (arrows) discovered by chance on the surface of the liver (corresponding to a somatic HNF1α-mutated adenomatosis). D: several yellow microadenomas in a somatic HNF1α-mutated adenomatosis; E: multiple not well limited steatotic microadenomas (asterix) nearby a larger adenoma (ad) in a patient with a constitutional HNF1α-mutated adenomatosis.