Basic Research
Copyright ©2007 Baishideng Publishing Group Co.
World J Gastroenterol. May 7, 2007; 13(17): 2496-2503
Published online May 7, 2007. doi: 10.3748/wjg.v13.i17.2496
Table 1 Pharmacokinetic data of fluoroquinolones from human studies
CompoundsPK parameters
References
1AUC0-∞ (μg·h/mL)
1t1/2(h)
1Cmax (mg/L)
No.NameRangeAverageRangeAverageRangeAverage
Training set
1Amifloxacin5.5-5.625.573.58-4.834.140.9-1.261.149, 10
2Balofloxacin8.558.557.87.81.081.0811
3Ciprofloxacin2.12-3.532.563.01-4.74.160.4-0.690.5612-15
4Clinafloxacin4.63-5.935.345.09-6.135.740.6-0.840.7216-18
5DW11618.54-23.321.8614.53-18.715.821.1-1.221.1719
6Enoxacin2.9-5.474.362.35-4.983.540.62-0.810.6620-22
7Gatifloxacin6.5-8.927.876.52-8.67.460.84-1.030.923-26
8Gemifloxacin2.79-3.433.025.87-8.26.650.46-0.730.5627-29
9Grepafloxacin2.83-4.053.439.2-12.711.530.24-0.410.3211, 12, 30, 31
10Levofloxacin8.96-9.59.336-7.46.780.16-0.30.2432-34
11Lomefloxacin8.05-13.539.845.5-12.77.730.95-1.181.0635-37
12Norfloxacin1.7-1.851.773.5-4.023.70.32-0.360.3338-40
13Ofloxacin6.68-11.647.674.6-6.75.320.71-1.330.8741-45
14Pefloxacin24.4-40.7829.9710.9-15.0614.631.03-1.681.4446-48
15Rufloxacin35.8-44.0339.4328.2-4034.250.68-1.130.9949-52
16Sitafloxacin5.62-6.025.884.6-75.40.9-0.930.9253-54
17Sparfloxacin8.08-11.968.3516.5-25.5620.060.23-0.40.3455-57
18Temafloxacin7.42-10.638.457.8-10.68.550.61-0.90.7458-60
19Trovafloxacin9.75-14.4711.917.8-10.89.660.97-1.51.2361-63
Test set
20Difloxacin26.6-28.327.820.6-28.825.71.02-1.11.0464
21Fleroxacin16.3-20.6518.137.9-1311.021.19-1.581.432, 65, 66
22Tosufloxacin1.49-3.32.623.6-4.854.020.21-0.40.3467-69