Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease

doi:10.3748/wjg.v13.i10.1579

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Mar 14, 2007; 13(10): 1579-1584
Published online Mar 14, 2007. doi: 10.3748/wjg.v13.i10.1579

Table 3 Multivariate analyses of factors associated with cardiovascular disease among 1221 subjects (748 men and 473 women)

Total (n = 1221)	Model 1		Model 2		Model 3
	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P
NAFLD	3.57 (1.47-8.67)	0.005	(-)	(-)	4.12 (1.58-10.75)	0.004
The metabolic syndrome	(-)	(-)	2.61 (1.03-6.60)	0.042	1.38 (0.49-3.86)	0.54
Age, 10 yr	1.61 (0.97-2.66)	0.064	2.08 (1.30-3.33)	0.002	2.12 (1.32-3.41)	0.002
The Brinkman index, 100 index¹	1.06 (0.97-1.16)	0.18	1.05 (0.96-1.14)	0.28	1.03 (0.95-1.12)	0.48
Systolic blood pressure, 10 mmHg	1.60 (1.26-2.04)	< 0.001	(-)	(-)	(-)	(-)
LDL-C, mmol/L	1.19 (0.70-2.03)	0.52	1.35 (0.8-2.3)	0.26	1.24 (0.73-2.08)	0.43
Men (n = 748)	Model 1		Model 2		Model 3
	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P
NAFLD	2.78 (0.98-7.89)	0.054	(-)	(-)	3.56 (1.16-10.95)	0.027
The metabolic syndrome	(-)	(-)	2.06 (0.70-6.11)	0.19	1.13 (0.34-3.78)	0.84
Age, 10 yr	1.59 (0.90-2.80)	0.11	1.90 (1.11-3.23)	0.019	1.96 (1.15-3.34)	0.014
The Brinkman index, 100 index¹	1.07 (0.97-1.18)	0.19	1.05 (0.95-1.15)	0.35	1.04 (0.95-1.13)	0.44
Systolic blood pressure, 10 mmHg	1.51 (1.10-2.07)	0.011	(-)	(-)	(-)	(-)
LDL-C, mmol/L	1.42 (0.74-2.71)	0.29	1.53 (0.81-2.90)	0.19	1.42 (0.76-2.65)	0.27
Women (n = 473)	Model 1		Model 2		Model 3
	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P	Odds ratio (95% CI)	P
NAFLD	14.33 (1.98-103.57)	0.008	(-)	(-)	7.32 (1.22-43.84)	0.029
The metabolic syndrome	(-)	(-)	4.59 (0.78-27.10)	0.093	2.86 (0.42-19.39)	0.28
Age, 10 yr	1.87 (0.60-5.78)	0.28	3.28 (1.09-9.86)	0.035	3.04 (0.99-9.31)	0.051
The Brinkman index, 100 index¹	0.46 (0.03-6.76)	0.57	0.55 (0.04-7.63)	0.65	0.41 (0.03-6.44)	0.53
Systolic blood pressure, 10 mmHg	1.88 (1.23-2.86)	0.003	(-)	(-)	(-)	(-)
LDL-C, mmol/L	0.62 (0.21-1.85)	0.39	0.87 (0.30-2.52)	0.80	0.77 (0.27-2.16)	0.62

NAFLD: nonalcoholic fatty liver disease; LDL-C: low dense lipoprotein cholesterol.

¹The Brinkman index is the number of cigarettes per day multiplied by years of smoking. A higher value indicates increased smoking-associated health hazard.

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Citation: Hamaguchi M, Kojima T, Takeda N, Nagata C, Takeda J, Sarui H, Kawahito Y, Yoshida N, Suetsugu A, Kato T, Okuda J, Ida K, Yoshikawa T. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol 2007; 13(10): 1579-1584
URL: https://www.wjgnet.com/1007-9327/full/v13/i10/1579.htm
DOI: https://dx.doi.org/10.3748/wjg.v13.i10.1579

Hamaguchi M, Kojima T, Takeda N, Nagata C, Takeda J, Sarui H, Kawahito Y, Yoshida N, Suetsugu A, Kato T, Okuda J, Ida K, Yoshikawa T. Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease. World J Gastroenterol 2007; 13(10): 1579-1584 [PMID: 17461452 DOI: 10.3748/wjg.v13.i10.1579]

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