Prior appendectomy and the phenotype and course of Crohn’s disease

Table 2 5-yr and 10-yr cumulative risks of intestinal and perianal complications in non-appendectomized and appendectomized patients according to disease location

		Non-appendectomized				Appendectomized
Location		L1	L2	L3	L4	L1	L2	L3	L4
Number of patients		493	546	513	218	279	172	186	79
Intestinal stricture	5-yr	23 ± 2	2 ± 1	9 ± 1	22 ± 3	30 ± 3 b	3 ± 2	12 ± 3	29 ± 6
	10-yr	34 ± 3	7 ± 1	17 ± 2	42 ± 5	46 ± 4 b	6 ± 2	24 ± 4	42 ± 7
Intestinal perforation	5-yr	30 ± 2	7 ± 1	12 ± 2	12 ± 2	27 ± 3	4 ± 2 a	13 ± 3	10 ± 4
	10-yr	42 ± 3	12 ± 2	25 ± 2	23 ± 4	37 ± 4	4 ± 2 a	23 ± 4	29 ± 7
Perianal fistulization	5-yr	14 ± 2	32 ± 2	31 ± 2	23 ± 3	11 ± 2	19 ± 3 b	26 ± 4	15 ± 4
	10-yr	18 ± 2	49 ± 3	41 ± 3	29 ± 4	17 ± 3	33 ± 5 b	40 ± 5	21 ± 6

^bP < 0.001,

^aP < 0.05 vs appendectomized non-appendectomized patients (log rank). Other curves were not significantly different.