Differences in oxidative stress dependence between gastric adenocarcinoma subtypes

Table 1 Correlation of staining with clinicopathologic data

Clinicopathologic featuresa	iNOSbNo. of casesTotal positive (%)	NTYRbNo. of casesTotal positive (%)	8OH-dGbNo. of casesTotal positive (%)
Infiltrative cancer subtypes	85 35 (41)	65 40 (62)	82 41 (50)
TC	54 291 (541)	43 312 ( 722)	54 28 (52)
DC	17 31 ( 181)	12 6 (50)	14 7 (50)
PolyC	14 31 (211)	10 32 ( 302)	14 6 (43)
Intraepithelial cancer
Periinfiltrative cancer	5 3 (60)	6 4 (67)	6 4 (67)
Without infiltrative cancer	7 1 (14)	7 6 (86)	10 5 (50)
Topography of infiltrative cancer
Cardia	10 4 (40)	7 3 (43)	11 5 (45)
Gastric stump	12 6 (50)	9 5 (56)	8 3 (38)
Antrum with angulus+pylorus	45 18 (40)	35 22 (63)	41 22 (54)
Body	14 7 (50)	11 9 (82)	15 11 (73)
Peritumorous mucosa
Adjacent: N + no IM G	15 5 (33)	23 9 (39)	30 10 (33)
Adjacent: atrophy IM	23 14 (61)	21 10 (48)	26 18 (69)
At distance: N + no IM G	3 1 (33)	6 1 (17)	5 2 (40)
At distance: atrophy IM	7 4 (57)	7 5 (71)	13 9 (69)
Adjacent+distant: N + no IM G`	18 6 (33)	29 10 (34)	35 123 (343)
Adjacent+distant: atrophy IM	30 18 (60)	28 15 (54)	39 27 (69)
Precancerous lesions
Low grade dysplasia	13 9 (69)	14 11 (79)	17 143 (823)
Atrophy IM without cancer	10 8 (80)	7 7 (100)	11 6 (55)
Atrophy IM with + without cancer	40 26 (65)	35 22 (63)	50 333 (663)
H pylori infection
Negative	68 27 (40)	54 35 (65)	77 41 (53)
Positive	18 7 (39)	13 7 (54)	16 9 (56)
Sex
Male	60 28 (47)	50 32 (64)	66 36 (55)
Female	30 8 (27)	29 20 (69)	35 18 (51)

(a) TC: Intestinal or tubular carcinoma; DC: Diffuse carcinoma; PolyC: Mixed polymorphous carcinoma; N: Normal; IM: Intestinal metaplasia; G: Gastritis. (b) iNOS: Inducible nitric oxide synthase; NTYR: Nitrotyrosine; 8OH-dG: 8-hydroxy-2’-deoxyguanosine.

¹TC vs DC P = 0.008; TC vs PolyC, P = 0.04; TC vs DC+PolyC, P = 0.04;

²TC vs PolyC. P = 0.03;

³non-metaplastic mucosa atrophic metaplastic mucosa low-grade dysplasia, P = 0.005.