Subfulminant hepatitis B after infliximab in Crohn’s disease: Need for HBV-screening?

Figure 1 ALT remained within the normal range during therapy with prednisolone, azathioprine and during the infusions with infliximab. Only after the fourth infusion of infliximab, the patient developed a fulminant hepatitis with ALT up to 1 100 IU/L. HBV-DNA ( ) quantification showed 220 mio copies/mL. Lamivudine (150 mg/d) was started and led to a rapid decrease in transaminases and HBV-DNA.