Concept on the pathogenesis and treatment of primary biliary cirrhosis

Figure 1 Hepatocytic ultrastructure. Digitonin-treated biopsy specimen. The specimen is contrasted with aqueous uranyl acetate and lead citrate. Deposits of cholesterol-digitonin complexes (the view of “tender spoondrift clouds”) are seen in the cytoplasm close to the mitochondria. The mitochondrial membrane forms pseudopodia here and there (indicated by arrow).