Attenuation of dextran sodium sulphate induced colitis in matrix metalloproteinase-9 deficient mice

Figure 4 TIMP-1 activity in DSS-induced colitis: A: Representative reverse zymograms in homogenates of colonic tissue in wild-type (wt) and MMP-9-deficient (KO) animals on d 5 (DSS 5) and 12 (DSS 12) after induction of colitis; B: Quantitative data of TIMP-1 activity (^aP < 0. 05 vs control) (n = 5 in each group); C: wt mice had a pro-MMP-9/TIMP-1 ratio significantly (^aP < 0.05) higher than controls on d 5 (DSS 5) and 12 (DSS 12) following the induction of colitis. The pro-MMP9/TIMP-1 ratio was not modified by DSS-induced colitis in KO mice.