Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients

Table 4 Allele and genotype frequencies of ARP, SPINK1 and CFTR gene polymorphisms in pancreatic cancers and controls

Polymorphisms	Cases(n = 61)	Controls(n = 105)
ARP
Allele frequencies
*1	4 (3.3)	4 (2.0)
*2	4 (3.3)	7 (3.0)
*3	111 (91.0)	195 (93.0)
*4	1 (0.8)	0 (0.0)
*5	1 (0.8)	2 (1.0)
*6	1 (0.8)	0 (0.0)
*7	0 (0.0)	2 (1.0)
CLUMP (T1): χ2 = 5.25 (df = 6), P = 0.52
Genotype frequencies
*1*3	4 (6.6)	4 (3.8)
*2*3	4 (6.6)	7 (6.7)
*3*3	50 (82.0)	90 (85.7)
*3*4	1 (1.6)	0 (0.0)
*3*5	1 (1.6)	2 (1.9)
*3*6	1 (1.6)	0 (0.0)
*3*7	0 (0.0)	2 (1.9)
CLUMP (T1): χ2 = 5.29 (df = 27), P = 0.54
SPINK1 (exon 3)
Allele frequencies
wt	117 (95.9)	206 (98.0)
P55S	4 (3.3)	2 (1.0)
N34S	1 (0.8)	2 (1.0)
CLUMP (T1): χ2 = 2.36 (df = 2), P = 0.29
Genotype frequencies
wt/wt	56 (91.8)	101 (96.2)
wt/P55S	4 (6.6)	2 (1.9)
wt/N34S	1 (1.6)	2 (1.9)
CLUMP (T1): χ2 = 2.40 (df = 5), P = 0.30
CFTR
Allele frequencies
wt	119 (97.5)	206 (98.0)
∆F508	3 (2.5)	4 (2.0)
CLUMP (T1): χ2 = 0.11 (df = 1), P = 1.0
Genotype frequencies
wt/wt	58 (95.1)	101 (96.2)
wt/∆F508	3 (4.9)	4 (3.8)
CLUMP (T1): χ2 = 0.11 (df = 2), P = 1.0

n (%)