Clinical Research
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Oct 7, 2006; 12(37): 6017-6020
Published online Oct 7, 2006. doi: 10.3748/wjg.v12.i37.6017
Table 2 Efficacy in the reference (racemic pantoprazole 40 mg, n = 182) and test (S-pantoprazole 20 mg, n = 187) groups
Symptomsd 0
d 14
d 28
P3
RefTestRefTestRefTest
Heart burnMean ± SD1.8 ± 0.81.9 ± 0.81.2 ± 0.81.2 ± 0.90.6 ± 0.90.6 ± 0.8< 0.0001
Median (Percentile 25th, 75th)2 (1.2)2 (1.3)1 (1.2)21 (0.5.2)10 (0.1)20 (0.1)1
RegurgitationMean ± SD1.6 ± 0.91.7 ± 0.91.1 ± 0.81 ± 0.80.5 ± 0.80.4 ± 0.6< 0.0001
Median (Percentile 25th, 75th)2 (1.2)2 (1.2)1 (0.2)21 (0.2)10 (0.1)20 (0.1)1
BloatingMean ± SD1.4 ± 0.91.4 ± 10.9 ± 0.90.8 ± 0.80.5 ± 0.80.3 ± 0.6< 0.0001
Median (Percentile 25th, 75th)1 (1.2)2 (1.2)1 (0.2)21 (1.2)10 (0.1)21 (1.1)1
NauseaMean ± SD1.4 ± 11.3 ± 10.8 ± 0.90.7 ± 0.80.4 ± 0.80.4 ± 0.7< 0.0001
Median (Percentile 25th, 75th)2 (0.2)1 (0.2)1 (0.2)20 (0.1)10 (0.0.25)20 (0.1)1
DysphagiaMean ± SD0.3 ± 0.60.5 ± 0.80.2 ± 0.60.2 ± 0.50.1 ± 0.40.1 ± 0.4< 0.001
Median (Percentile 25th, 75th)0 (0.0)0 (0.1)0 (0.0)0 (0.0)10 (0.0)0 (0.0)1