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Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 21, 2006; 12(31): 4943-4950
Published online Aug 21, 2006. doi: 10.3748/wjg.v12.i31.4943
Table 2 Conditions and clinical scenarios that may mimic Lynch syndrome
Attenuated Familial Adenomatous Polyposis[37] (polyps may not be numerous)
MYH polyposis[38] (polyps may not be numerous)
Juvenile polyposis[66] (polyps may not be numerous and may be adenomatous)
Germline mutation of TGFbetaRII[67] and AXIN2[68] (is not associated with DNA MSI)
Hereditary mixed polyposis syndrome[69] (polyps may not be numerous and may be adenomatous)
Hyperplastic polyposis[53] (polyps may not be numerous and may be adenomatous)
Serrated Pathway Syndrome[54] (polyps may not be numerous and may be adenomatous and CRCs may show DNA MSI)
Germline hemi-allelic methylation of MLH1[48-51] (multiple, early onset cancers with Lynch syndrome spectrum and having DNA MSI)
Lynch syndrome variants[61,65] (autosomal recessive Turcot syndrome due to PMS2 mutation)
Familial Colorectal Cancer-Type X[40] (Amsterdam criteria met but Lynch syndrome and conditions listed above have been excluded)