Cross-species hybridization of woodchuck hepatitis virus-induced hepatocellular carcinoma using human oligonucleotide microarrays

Table 4 Top 10 up- and down-regulated genes in common on all three tumor/normal sample pairs

Fold change1	Gene title	Gene symbol	Location	Process	Agreement
14.3294	Stearoyl-CoA desaturase (delta-9-desaturase)	SCD	10q23-q24	Fatty Acid Biosynthesis	[7]
11.6297	ELOVL family member 6, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)	ELOVL6	4q25	Fatty Acid Biosynthesis	[8]
7.7381	Chromosome 9 open reading frame 41	C9orf41	9q21.13		none
5.1036	Cytochrome P450, family 51, subfamily A, polypeptide 1	CYP51A1	7q21.2-q21.3	Electron Transport/ Cholesterol Biosynthesis	[9]
4.1746	H2A histone family, member Z	H2AFZ	4q24	DNA Replication	[10]
3.4227	H2A histone family, member Z	H2AFZ	4q24	DNA Replication	[10]
3.3977	TATA box-binding protein-like protein 1, TBP-like 1	TBPL1	6q22.1-q22.3	Transcription	none
2.9307	Diacylglycerol O-acyltransferase homolog 2 (mouse)	DGAT2	11q13.5	Triacylglycerol biosynthesis	[11]
2.8134	ARP2 actin-related protein 2 homolog (yeast)	ACTR2	2p14	Protein Binding/Structural Molecule Activity	[12,13]
2.8134	Calcium binding protein P22	CHP	15q13.3	Potassium Ion Transport/Small GTPase Mediated Signal Transduction	[14]
-3.6151	Metallothionein 1H	MT1H	16q13	Metal Ion Binding	[15,16]
-3.6353	Metallothionein 2A	MT2A	16q13	Metal Ion Binding	[15,16]
-3.9071	Metallothionein 1X	MT1X	16q13	Metal Ion Binding	[15,17]
-4.1870	EST similar to early growth response 1				[18,19]
-4.5774	Metallothionein 1F (functional)	MT1F	16q13	Metal Ion Binding	[15,16]
-4.9625	Early growth response 1	EGR1	5q31.1	Regulation of Transcription	[18,19]
-5.5956	Metallothionein 1F (functional)	MT1F	16q13	Metal Ion Binding	[15,16]
-5.7266	Sprouty homolog 2 (Drosophila)	SPRY2	13q31.1	Cell-Cell Signaling/ Development/ Organogenesis/ Regulation of Signal Transduction	[20]
-10.3842	Early growth response 1	EGR1	5q31.1	Regulation of Transcription	[18,19]
-24.2139	Insulin-like growth factor binding protein 2, 36 kDa	IGFBP2	2q33-q34	Regulation of Cell Growth	[21]

¹This is the average fold change for all 3 HCC vs normal sample pairs.