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©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jun 7, 2006; 12(21): 3338-3343
Published online Jun 7, 2006. doi: 10.3748/wjg.v12.i21.3338
Published online Jun 7, 2006. doi: 10.3748/wjg.v12.i21.3338
Table 2 Effect of IFN alpha on serum fibrosis markers in children with chronic hepatitis B (mean±SD)
| Patients | Marker(μg/L) | Before IFN(1) | After IFN(2) | 12 mo after IFN (3) | P1 vs 2 | P1 vs 3 | P2 vs 3 |
| All n = 47 | TIMP-1 | 558.1 ± 121.2 | 569.2 ± 134.8 | 636.9 ± 125.8 | NS | b | NS |
| CollagenVI | 5.8 ± 2.2 | 6.2 ± 1.8 | Nd | NS | - | - | |
| Tenascin | 748.8 ± 266.0 | 641.5 ± 216.8 | 764.0 ± 250.0 | b | NS | b | |
| Hyaluronan | 34.3 ± 21.5 | 40.0 ± 30.9 | 28.7 ± 19.3 | NS | b | b | |
| Responders n = 20 | TIMP-1 | 544.1 ± 120.3 | 555.4 ± 109.3 | 608.0 ± 134.9 | NS | NS | NS |
| CollagenVI | 5.6 ± 1.85 | 6.7 ± 1.8 | Nd | NS | - | - | |
| Tenascin | 766.2 ± 289.9 | 686.2 ± 225.8 | 765.5 ± 249.9 | NS | NS | NS | |
| Hyaluronan | 40.3 ± 28.1 | 36.8 ± 18.0 | 30.7 ± 17.2 | NS | a | a | |
| Non Responders n = 27 | TIMP-1 | 567.9 ± 123.1 | 581.2 ± 155.0 | 657.2 ± 118.3 | NS | b | NS |
| CollagenVI | 6.0 ± 2.4 | 5.7 ± 1.7 | Nd | NS | - | - | |
| Tenascin | 736.6 ± 252.7 | 602.6 ± 205.6 | 762.9 ± 254.9 | b | NS | b | |
| Hyaluronan | 29.6 ± 13.6 | 42.7 ± 39.1 | 27.2 ± 20.9 | NS | NS | b |
- Citation: Lebensztejn DM, Sobaniec-Lotowska ME, Kaczmarski M, Voelker M, Schuppan D. Matrix-derived serum markers in monitoring liver fibrosis in children with chronic hepatitis B treated with interferon alpha. World J Gastroenterol 2006; 12(21): 3338-3343
- URL: https://www.wjgnet.com/1007-9327/full/v12/i21/3338.htm
- DOI: https://dx.doi.org/10.3748/wjg.v12.i21.3338