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Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. May 28, 2006; 12(20): 3229-3236
Published online May 28, 2006. doi: 10.3748/wjg.v12.i20.3229
Figure 2
Figure 2 Schematic of acid secretion. A: Classically defined pathway of acid secretion: Gastrin released from the G cell binds to receptors on the ECL cell causing histamine release from the ECL cell. The histamine binds to receptors on the parietal cell and stimulates proton efflux; B: Modified model of acid secretion involving a functional CaSR on the basolateral membrane of both the G cell and parietal cell. Acid secretion can be activated directly by the CaSR on the parietal cell or via the G cell pathway.