Editorial
Copyright ©2006 Baishideng Publishing Group Co.
World J Gastroenterol. Jan 14, 2006; 12(2): 181-186
Published online Jan 14, 2006. doi: 10.3748/wjg.v12.i2.181
Figure 1
Figure 1 Deregulation of SHP-2 tyrosine phosphatase by the H pylori virulence factor CagA. CagA is delivered into gastric epithelial cells by the bacterial type IV secretion system. CagA deregulates the SHP2 oncoprotein. CagA is noted for its variation, particularly at the SHP2-binding site.