Reconstruction of liver organoid using a bioreactor

Figure 11 RFB and intact organ. A: In the RFB system, culture medium flows from outside the column toward the center of the reactor. Medium flows faster at the center than at the periphery. Biases in distribution of oxygen and nutrition at inflow and outflow are minimized. B: In the hepatic lobe, blood flows from the portal vein to central vein. The RFB system is similar to the organization of the hepatic primary lobe[31]. Figure 11B is reproduced from Figure 9 in reference 31.