DNA end binding activity and Ku70/80 heterodimer expression in human colorectal tumor

Figure 2 Changes in Ku70/Ku80 heterodimer DNA binding activity in adenoma (A) and carcinoma (B) compared to matched normal colonic mucosa. Normal; Tumor; vertical bars indicate standard deviation from the mean of three independent experiments. Adenomas (A) and carcinomas (B) samples characterize by: Group 1 more than 50% increase in DNA binding activity; Group 2 modest increase in binding activity; Group 3 reduced binding activity, ¹P<0.000 vs group 1; ²P<0.04 vs group 3; ³P<0.02 vs group 2.