Significance and prognostic value of lysosomal enzyme activities measured in surgically operated adenocarcinomas of the gastroesophageal junction and squamous cell carcinomas of the lower third of esophagus

Table 1 Specific activities of lysosomal enzymes in 29 adenocarcinomas of the GEJ and surrounding normal mucosa (mean±SE)

Enzymes	Adenocarcinoma	Normal gastric mucosa	P
AGLU	27315 ± 3139	31210 ± 2490	NS
AMAN	89594 ± 8518	66653 ± 4066	<0.05
BGAL	318224 ± 43694	245442 ± 15421	NS
CB	324095 ± 39402	167582 ± 14842	<0.001
CL	392438 ± 44328	296166 ± 29044	NS
DPP I	2140499 ± 287604	1291759 ± 126796	<0.05
CH	491813 ± 51110	404285 ± 40939	NS
DPP II	80982 ± 9916	110728 ± 15265	NS
GCU	219615 ± 42364	178776 ± 18607	NS
HEX	213292 ± 28785	186396 ± 18779	NS
TPP I	921939 ± 328332	443130 ± 134508	NS
THP	36271 ± 14639	23382 ± 10817	NS

GEJ: gatroesophageal junction; NS: non significant; AGLU: α-glucosidase; AMAN: α-mannosidase; BGAL: β-galactosidase; CB: cathepsin B; CL: cathepsin L; DPP I: dipeptidyl-peptidase I; CH: cathepsin H; DPP II: dipeptidyl-peptidase II; GCU: β-glucuronidase; HEX: β-hexosaminidase B; TPP I: tripeptidyl-peptidase I; THP: thimet oligopeptidase (pmol /h·mg).