Recurrent chromosomal rearrangements at bands 8q24 and 11q13 in gastric cancer as detected by multicolor spectral karyotyping

Figure 3 FISH and SKY analysis on SNU16. A: DC-FISH using YAC probe I2 (8q24.1, red) and cosmid probe CPP29 (11q13.3, green). I2 probe shows periodic staining pattern on HSRs, indicating amplification of MYC gene on HSRs but not double minute chromosomes (DMs). Three copies of CCDN1 gene are detected; B: Inverted DAPI band image of the same metaphase plate shown in A; C: SKY findings of HSRs found in SNU16. Three HSRs were initially identified as originating from chromosome no. 2 based on their fluorescence color.