Relationship between metabolic enzyme polymorphism and colorectal cancer

Table 3 Results of meta-analysis of polymorphisms and risk for colorectal cancer in group B.

Gene and polymorphism	Study numbers	Cumulative cases	Cumulative controls	Test of heterogeneity		Statistical method	OR	95% CI	Significance P
				χ	P
GSTM1 deletion	14	3002	3911	20.54	0.08	Fixed	1.07	0.97-1.17	0.2
GSTT1 deletion	8	1029	1492	12.52	0.085	Fixed	1.20a	1.00-1.44	0.05
GSTP1 lle105Val	4	609	755	3.63	0.3	Fixed	1.08	0.86-1.35	0.5
NAT1*10	3	520	433	5.2	0.07	Fixed	1.2	0.92-1.56	0.18
NAT2-rapid acetylator p&g	12	3121	3697	13.61	0.26	Fixed	1.02	0.92-1.13	0.7
NAT2-rapid acetylator p	6	2038	2546	8.91	0.11	Fixed	1.06	0.94-1.20	0.3
NAT2-rapid acetylator g	6	1083	1151	3.62	0.61	Fixed	0.95	0.79-1.13	0.5
CYP1A1 Lle462Val	2	235	280	1.62	0.2	Fixed	1.17	0.71-1.91	0.5
CYP1A1 MspI*C	2	234	280	5.01	0.03	Random	1.21	0.77-1.90	0.4
METHFR C677T	3	546	1 413	1.38	0.5	Fixed	0.69a	0.51-0.94	0.02
MTR A2759G	2	356	476	0	0.98	Fixed	0.6	0.28-1.29	0.19

Fixed: Fixed-effect model, Random: Random-effects model.

^aP<0.05.