High level of hepatitis B virus DNA after HBeAg-to-anti-HBe seroconversion is related to coexistence of mutations in its precore and basal core promoter

Table 3 Main clinical data of 147 serum samples with G1896A and/or A1762T/G1764A mutations.

	G1896A only (n = 64)	A1762T/G1764A only (n = 19)	Coexistence (n = 64)
Age (yr)	40.5±12.8	43.2±14.2	40.7±12.8
Sex (no. male/no. female)	55/9	18/1	May-59
Alanine aminotransferase (IU/L)	101.9±158.3	121.8±183.1	116.7±137.3
Total bilirubin (mmol/L)	25.2±39.2	24.8±40.6	32.5±55.2b
Serum albumin (g/L)	38.4±5.3	39.1±5.8	37.7±5.3d
Clinical diagnosis
Chronic hepatitis Mild (n)	23	3	13
Median (n)	20	10	14
Gravies (n)	12	4	22f
Liver cirrhosis	9	2	15g

¹t = –2.85,

^bP<0.01, ²t = 6.37,

^dP<0.01, compared with group of G1896A only. ³χ² = 18.3, fP<0.01, ⁴χ² = 4.03,

^gP<0.05, compared with group of mild type of chronic hepatitis B.