Preparation and characteristics of DNA-nanoparticles targeting to hepatocarcinoma cells

Table 1 Distribution (%) of ³²P-DNA in mice after intravenous administration of ³²P-DNA (n = 5)

Time	Heart	Liver	Spleen	Lung	Kidney	Blood
5 min	3.14 ± 0.60	36.67 ± 2.65	3.56 ± 1.58	16.32 ± 0.79	23.52 ± 1.48	16.79 ± 1.62
15 min	3.15 ± 0.97	41.26 ± 2.89	5.25 ± 0.86	14.16 ± 0.99	20.61 ± 1.62	15.57 ± 1.58
30 min	6.94 ± 1.57	52.59 ± 4.02	10.46 ± 0.75	7.95 ± 0.58	13.10 ± 0.85	2.95 ± 0.65
1 h	6.11 ± 1.95	54.62 ± 3.12	14.85 ± 1.23	7.82 ± 0.67	13.50 ± 0.94	3.10 ± 0.78
2 h	4.56 ± 1.01	51.34 ± 2.88	14.93 ± 0.68	9.65 ± 1.41	15.03 ± 1.34	4.49 ± 0.28
6 h	5.12 ± 0.79	48.66 ± 1.87	13.15 ± 0.84	9.66 ± 1.27	18.26 ± 1.58	5.15 ± 1.67
12 h	5.48 ± 0.99	44.52 ± 2.02	11.32 ± 1.33	11.36 ± 1.34	21.83 ± 2.54	5.49 ± 0.58
24 h	3.93 ± 0.65	43.31 ± 1.67	11.48 ± 1.11	10.12 ± 0.64	25.01 ± 3.12	6.16 ± 0.94
48 h	3.43 ± 0.84	36.75 ± 1.65	11.56 ± 0.82	13.36 ± 1.60	28.52 ± 2.15	6.38 ± 0.83
72 h	4.52 ± 0.77	34.48 ± 1.85	12.03 ± 1.73	13.88 ± 1.63	28.31 ± 3.01	6.78 ± 0.91