Inhibition of DNA primase and induction of apoptosis by 3,3’-diethyl-9-methylthia-carbocyanine iodide in hepatocellular carcinoma BEL-7402 cells

Figure 2 Inhibitory effect of DMTCCI on DNA primase activity. Appropriate amounts of DMTCCI were incubated with the standard reaction mixture containing DNA primase-poly-merase complex purified from mice Ehrilich’s ascites carci-noma cells for 30 min at 37 °C. DNA primase reaction was mea-sured by the formation of RNA oligomers. Results were ex-pressed as mean ± SD for three independent experiments.