Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population

doi:10.3748/wjg.v10.i20.3056

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Oct 15, 2004 (publication date) through Apr 17, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 15, 2004; 10(20): 3056-3059
Published online Oct 15, 2004. doi: 10.3748/wjg.v10.i20.3056

Table 2 CTLA-4 promoter –318 polymorphism in patients with AIH, PBC and controls

	Control (% )	AIH (%)	P	PBC (%)	P
Genotype frequencies			0.10		0.55
C/C	122 (76.3)	54 (87.1)		3 (81.8)
C/T	30 (18.8)	8 (12.9)		12 (15.6)
T/T	8 (5.0)	0 (0)		2 (2.6)
Allele⁽¹⁾			0.02		0.23
C	274 (85.6)	116 (93.6)		138 (89.6)
T	46 (14.4)	8 (6.5)		16 (10.4)
Phenotype frequencies⁽²⁾			0.11		0.39
C positive	152 (95.0)	62 (100)		75 (97.4)
T positive	38 (23.8)	8 (12.9)		14 (18.2)

¹Odds ratio for C allele (AIH) = 0.41, 95%CI = 0.19-0.90; Odds ratio for C allele (PBC) = 0.69, 95%CI = 0.38-1.26, ²Odds ratio for C phenotype (AIH) = 0.52, 95%CI = 0.23-1.17; Odds ratio for C phenotype (PBC) = 0.75, 95%CI = 0.38-1.46.

Citation: Fan LY, Tu XQ, Cheng QB, Zhu Y, Feltens R, Pfeiffer T, Zhong RQ. Cytotoxic T lymphocyte associated antigen-4 gene polymorphisms confer susceptibility to primary biliary cirrhosis and autoimmune hepatitis in Chinese population. World J Gastroenterol 2004; 10(20): 3056-3059
URL: https://www.wjgnet.com/1007-9327/full/v10/i20/3056.htm
DOI: https://dx.doi.org/10.3748/wjg.v10.i20.3056