Long term persistence of T cell memory to HBsAg after hepatitis B vaccination

Table 1 Lymphocyte proliferation to HBsAg in controls and vaccine recipients

Group	n	anti-HBs Titer	Net count	T cell	ConA	Tetanus +
		(IU/L)	(mean)	proliferation positive	stimulation (mean ± SD)	diphtheria (mean ± SD)
1	9	unvaccinated	252a	0/9 (0%)	61 000 ± 29 058	19075 ± 13 688
2	12	≤ 10	2 810a,b	7/12 (58%)	55 203 ± 25 071	10651 ± 7 533
3	6	11-100	4 718b	6/6 (100%)	35 273 ± 33 140	19448 ± 16 171
4	13	> 100	12 167	13/13	40 668 ± 20 695	21266 ± 17 025

net count = mean cpm of medium,

^aP-value of statistical comparison of net counts of group II (anti-HBs ≤10 IU/L) with group I (unvaccinated control): P = 0.0093,

^bP-value of statistical comparison of group II with group III + group IV (anti-HBs > 10 IU/L): P = 0.0022 (Mann-Whitney).