Leflunomide attenuates hepatocyte injury by inhibiting Kupffer cells

Figure 2 Changes of TNF-α and IL-1 levels in culture superna-tants of HC, DC, KC after 4 h and 24 h incubation with various concentrations of LPS (n = 3, mean ± SD). ^bP < 0.01 for TNF-α and IL-1 levels in DC, KC vs control; ^dP < 0.01 for DC coculture vs other cultures after 0, 1, 5, and 10 µg/mL LPS. A: Changes of TNF-α levels in culture supernatants of HC, DC, KC after 4 h incubation with various concentrations of LPS. B: Changes of IL-1 levels in culture supernatants of HC, DC, KC after 24 h incubation with various concentrations of LPS.