Constitutive activation of Stat3 signaling pathway in human colorectal carcinoma

Table 1 Clinicopathological parameters of 45 patients with colorectal carcinoma

Clinicopathological parameters		Numbers (%)
Gender	Male	24 (53.3)
	Female	21 (46.7)
Age (yr)	Range	35-81
	Mean	61.7
	Median	66.0
Primary site	Colon	25 (55.6)
	Rectum	20 (44.4)
	I	1 (0.22)
	II	24 (53.3)
	III	14 (31.1)
	IV	6 (13.3)
Depth of invasion and Lymph node involvement	T1-T2 N0	7 (15.6)
	T3-T4 N0	18 (40.0)
	T1-T2 N1-2N2	12 (26.7)
	T3-T4 N1-N2	8 (17.8)
Distant Metastasis	M0	39 (86.7)
	M1	6 (13.3)
Histological grade	G1	12 (26.7)
	G2	22 (48.9)
	G3	11 (24.4)
Tumor size	> 5 cm	22 (48.9)
	≤ 5 cm	23 (51.1)

T1: tumor invades the submucosa; T2: tumor invades the muscularis propria; T3: tumor invades through the muscularis pro-pria into the subserosa or perirectal tissues; T4: tumor directly invades other organs or structures and/or perforates visceral peritoneum; N0: no regional lymph node metastasis; N1: me-tastasis in one to three regional lymph nodes; N2: metastasis in four or more regional lymph nodes; M0: no distant metastasis; M1: distant metastasis; G1: well differentiated tumor; G2: mod-erately differentiated tumor; G3: poorly differentiated tumor.