Gender difference in clinicopathologic features and survival of patients with hepatocellular carcinoma

Table 2 Clinicopathologic data of female and male patients with HCC at initial diagnosis

Characteristics	Female (n = 39)	Male (n = 260)	P
Mean tumor size (cm)	8.1 ± 3.9	11.6 ± 4.5	0.02
Tumor size
≤5 cm:> 5 cm	9:30	30:230	0.04
Gross appearance of HCC
Nodular:Multinodular:Massive:Diffuse	12:10:14:3	30:52:115:63	0.01
Tumor cell differentiation
Well:Moderately:Poorly	3:5:4	11:66:32	NS
Okuda’ s staging (I:II:III)	13:23:3	43:180:37	0.04
Portal or hepatic vein invasion (+:-)	6:33	84:176	0.03
Extrahepatic metastasis (+:-)	5:34	37:223	NS
Ruptured HCC (+:-)	1:38	29:231	NS
Therapy for HCC (+:-)	22:17	105:155	NS
Modality of therapy
Surgical resection (+:-)	9:30	27:233	0.02
Chemoembolization (+:-)	13:26	43:217	0.01
Systemic chemotherapy (+:-)	0:39	31:229	0.02

Quantitative variables were expressed as mean ± SD; (+:-) indicates positive:negative.