Gender difference in clinicopathologic features and survival of patients with hepatocellular carcinoma

Table 1 Demographic and clinical data of female and male patients with HCC at initial diagnosis

Characteristics	Female (n = 39)	Male (n = 260)	P
Age (yr)	56.4 ± 15.2	52.6 ± 13.2	NS
Underlying cirrhosis (+:-)	36:3	251:9	NS
Viral hepatitis marker
HBsAg (+:-)	18:21	147:113	NS
Anti-HCV (+:-)	5:34	23:237	NS
Heavy alcohol consumption (+:-)	3:36	83:177	0.002
Mean AFP (IU/mL)	48435.4 ± 105231.6	40221.9 ± 89147.9	NS
Biochemical liver function tests
Total bilirubin (mg/dL)	1.5 ± 1.2	3.1 ± 2.3	0.03
Alkaline phosphatase (IU/L)	451.6 ± 277.3	529.3 ± 375.0	NS
AST (IU/L)	128.4 ± 133.2	154.3 ± 135.2	NS
ALT (IU/L)	62.7 ± 52.6	87.6 ± 97.5	NS
Albumin (g/dL)	3.6 ± 0.7	3.4 ± 0.7	NS
Prothrombin time (sec)	14.5 ± 2.8	15.1 ± 9.3	NS

Quantitative variables were expressed as mean ± SD; (+:-) indicates positive:negative. NS = not significant.