Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

Figure 1 Scheme of the minocyclines’ mechanism of action. Amino acids and tRNAs are linked together by aminoacyl-tRNA synthetase to produce specific Aminoacyl-tRNAs. ribosomes on the ribosomal complex then read the code along the 5’-3’ direction of the mRNAs while linking various aminoacyl-tRNA-transported amino acids according to the instructions of the mRNA coding sequences for the process of protein synthesis. When minocycline enters into bacteria, it specifically binds to the A site of bacterial ribosomal 30S subunit aminoacyl group, thus blocking the aminoacyl-tRNA binding at this site, preventing peptide chain elongation and bacterial protein synthesis, and exerting bactericidal effects. AA: Amino acids.

Figure 2 Literature identification process.

Figure 3 Forest plots comparing eradication rates for intention-to-treat and per-protocol analyses of quadruple regimens with and without minocycline. CI: Confidence interval.

Figure 4 Forest plots comparing eradication rates for intention-to-treat and per-protocol analyses of quadruple regimens with and without minocycline-metronidazole. CI: Confidence interval.

Figure 5 Comparison of the incidence of adverse reactions of quadruple therapy and dizziness in quadruple therapy with and without minocycline. A: Comparison of the incidence of adverse reactions of quadruple therapy with and without minocycline; B: Comparison of the incidence of dizziness in quadruple therapy with and without minocycline. CI: Confidence interval.

Figure 6 Funnel plots of all included studies through intention-to-treat and per-protocol analyses. A: Intention-to-treat analyses; B: Per-protocol analyses.

Figure 7 Sensitivity analysis of all included studies by sequentially removing each study with intention-to-treat and per-protocol analyses. A: Intention-to-treat analyses; B: Per-protocol analyses. CI: Confidence interval.