Reduced expression of circulating microRNA-218 in gastric cancer and correlation with tumor invasion and prognosis

Figure 1 Expression of microRNA-218. A: Expression of microRNA (miR)-218 in the serum of gastric cancer patients (n = 68) and healthy controls (n = 56) (^aP = 0.026); B: Relationship between expression of miR-218 and tumor stages I/II (n = 40) and III/IV (n = 28) (^aP = 0.023); C: Relationship between expression of miR-218 and well-differentiated (n = 26) and poorly differentiated (n = 18) tumor (^aP = 0.025); D: Relationship between expression of miR-218 and tumor metastasis (n = 28) and non-metastasis (n = 40) (^aP = 0.031).

Figure 2 Kaplan-Meier estimates of cumulative overall survival by microRNA-218. Significant difference was observed between the high and low microRNA (miR)-218 subgroups indicating the predictive value of miR-218 for gastric cancer (P = 0.008).