Plasmablastic lymphoma of the small intestine: Case report and literature review

Figure 1 Plasmablastic lymphoma of the small intestine. A: Diffuse infiltration in the mucosa of the small intestinal by monotonous large atypical lymphoid cells [hematoxylin and eosin (H and E), original magnification ×200]; B: These atypical cells had a plasmablastic appearance, with abundant basophilic cytoplasm, eccentrically located pleomorphic nuclei, and single, centrally located prominent nucleoli (H and E, original magnification ×400); C-F: The atypical cells were diffusely positive for CD79a (C), CD138 (D), CD10 (E) and immunoglobulin light chain κ (F) (immunoperoxidase stain, original magnification ×400); G: Nuclear proliferation rate as assessed by Ki-67 staining was approximately 80% (immunoperoxidase stain, original magnification ×400); H: Epstein-Barr virus (EBV)-encoded RNA in situ hybridization for EBV shows negative staining in the nucleus of these atypical cells (original magnification ×400).