Tumor metastasis and the reciprocal regulation of heparanase gene expression by nuclear factor kappa B in human gastric carcinoma tissue

Figure 1 Comparison of nuclear staining rates statistically higher in tumor cells with those in adjacent and normal epithelial cells after staining of RelA. A: Normal epithelial cells with no nuclei staining; B: Adjacent epithelial cells with no nuclei staining; C: Cancer tissues with strong nuclei staining; D: Cancer metastasis to the liver with specially enhanced nuclei staining (×400).

Figure 2 Increased NF-κB RelA (p65) DNA binding activities in tumor specimens compared with that in adjacent and normal tissue of 2 typical cases.

Figure 3 The significantly higher heparanase mRNA levels in gastric cancer specimens than those in adjacent and far normal specimens of 4 typical cases.