Inactivation of PTEN is associated with increased angiogenesis and VEGF overexpression in gastric cancer

Figure 1 Expression of PTEN. A: Strongly positive expression in bening gastric glandular epithelium cells (Immunohistochemical staining, S-P × 400). B: Positive expression in moderately differentiated cancer cells (Immunohistochemical staining, S-P × 100). C: Weakly positive expression in poorly differentiated cancer cells. (Immunohistochemical staining, S-P × 400).

Figure 2 Expression of VEGF. A: Weakly positive expression in benign gastric glandular epithelium cells. B: Strongly positive expression in poorly differentiated cancer cells. (Immunohistochemical staining, S-P × 400).

Figure 3 MVD in benign/malignant gastric tissues. A: Lessand weakly stained microvessel labeled by CD34 was regularly distributed among the benign gastric epithelium gland (Immunohistochemical staining, S-P × 400). B: Increased and strongly stained microvessel labeled by CD34 was irregularly infiltrated in poorly differentiated adenocarcinoma (Immunohistochemical staining, S-P × 200).