NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis

doi:10.3748/wjg.v13.i45.6003

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World Journal of Gastroenterology

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1007-9327

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Clinical Research

World J Gastroenterol. Dec 7, 2007; 13(45): 6003-6008
Published online Dec 7, 2007. doi: 10.3748/wjg.v13.i45.6003

NAT2*6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis

Norihide Higuchi, Naoko Tahara, Katsunori Yanagihara, Kiyoyasu Fukushima, Naofumi Suyama, Yuichi Inoue, Yoshitsugu Miyazaki, Tsutomu Kobayashi, Koh-ichiro Yoshiura, Norio Niikawa, Chun-Yang Wen, Hajime Isomoto, Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto

Norihide Higuchi, Naoko Tahara, Tsutomu Kobayashi, Kazuhiro Tsukamoto, Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan

Katsunori Yanagihara, Yoshitsugu Miyazaki, Hajime Isomoto, Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Second Department of Internal Medicine, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8501, Japan

Kiyoyasu Fukushima, Division of Internal Medicine, Japanese Red Cross Nagasaki Genbaku Isahaya Hospital, Isahaya 859-0497, Japan

Naofumi Suyama, Department of Internal Medicine, Nagasaki Municipal Medical Center, Nagasaki 852-8012, Japan

Yuichi Inoue, Department of Internal Medicine, Isahaya Health Insurance General Hospital, Isahaya 854-8501, Japan

Koh-ichiro Yoshiura, Norio Niikawa, Department of Human Genetics, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-12-4, Nagasaki 852-8523, Japan

Koh-ichiro Yoshiura, Norio Niikawa, Kazuhiro Tsukamoto, SORST, JST, Kawaguchi, Japan

Chun-Yang Wen, Department of Digestive Disease Center, Beihua University, Jilin 132013, Jilin Province, China

Author contributions: All authors contributed equally to the work.

Supported by Grant-in-Aid for Scientific Research (Category B, No. 18390168) for K Tsukamoto by the Ministry of Education, Culture, Sports, Science and Technology of Japan

Correspondence to: Professor Kazuhiro Tsukamoto, Department of Pharmacotherapeutics, Nagasaki University Graduate School of Biomedical Sciences, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan. ktsuka@nagasaki-u.ac.jp

Telephone: +81-95-8192447 Fax: +81-95-8192895

Received: December 18, 2006
Revised: September 3, 2007
Accepted: October 25, 2007
Published online: December 7, 2007

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