In 2019, the World Journal of Gastroenterology (WJG) has published the 5^th issue which containing 9 articles including 3 reviews, and 6 original articles, contributed by scientists worldwide. Among these comprehensive articles are (1) “Iron and liver fibrosis: Mechanistic and clinical aspects”, a Review by Kosha J Mehta, PhD, Senior Lecturer, et al from Division of Human Sciences, School of Applied Sciences, London South Bank University, United Kingdom; (2) “Effect of adipose-derived mesenchymal stem cells on hepatocellular carcinoma: In vitro inhibition of carcinogenesis”, a Basic Study by Nada Alaaeddine, PhD, Professor, et al from Laboratoire d’Immunologie Cellulaire et Moléculaire, Centre Hospitalier de l’Université de Montréal, Canada; and (3) “Analysis of intrahepatic sarcomatoid cholangiocarcinoma: Experience from 11 cases within 17 years”, a Retrospective Study by Yang Hyun Baek, MD, PhD, Associate Professor, et al from Department of Internal Medicine, Dong-A University College of Medicine, South Korea, etc. We invite you to peruse all 9 articles in this issue, as they present the latest research progress/findings and provide insightful comments in gastroenterology and hepatology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 25, Issue 5, February 7, 2019.

Figure 1 The cover of the issue. Editorial board member of World Journal of Gastroenterology, Amedeo Amedei, BSc, Professor, Department of Experimental and Clinical Medicine, University of Florence, Firenze 50134, Italy.

We encourage gastroenterologists and hepatologists worldwide to submit manuscripts to the WJG describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.