In 2019, the World Journal of Gastroenterology (WJG) has published the 2^nd issue which containing 10 articles including 4 reviews, and 6 original articles, contributed by scientists worldwide. Among these comprehensive articles are (1) “Role of diet and gut microbiota on colorectal cancer immunomodulation”, a Review by Amedeo Amedei, Associate Professor, et al from Department of Experimental and Clinical Medicine, University of Florence, Italy; (2) “Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer”, a Basic Study by Ausra Lukosiute-Urboniene, MD, Doctor, Surgeon, et al from Institute for Digestive System Research, Lithuanian University of Health Sciences, Lithuania; and (3) “Novel abdominal negative pressure lavage-drainage system for anastomotic leakage after R0 resection for gastric cancer”, a Retrospective Study by Chang-Ming Huang, MD, Doctor, Professor, et al from Department of Gastric Surgery, Fujian Medical University Union Hospital, China, etc. We invite you to peruse all 10 articles in this issue, as they present the latest research progress/findings and provide insightful comments in gastroenterology and hepatology that will guide basic research and clinical practice in these fields.

This journal is an open-access journal which allows free immediate access to all full-text articles. For details, please visit: Volume 25, Issue 2, January 14, 2019.

Figure 1 The cover of the issue. Editorial board member of World Journal of Gastroenterology, Andreas Larentzakis, MD, MSc, PhD, Academic Fellow, Attending Doctor, Doctor, Surgeon, Surgical Oncologist, Department of Surgery, Athens Medical School, National snd Kapodistrian University of Athens, Athens 11527, Greece

We encourage gastroenterologists and hepatologists worldwide to submit manuscripts to the WJG describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.

We invited the readers to download and read the E-Journal of this issue.