In 2017, the World Journal of Gastroenterology (WJG) has published the 40^th issue which containing 16 articles including 1 Minireview, 12 Original Articles, 2 Case Reports and 1 Letter contributed by scientists worldwide. Among these comprehensive articles are (1) “Non-celiac gluten sensitivity: All wheat attack is not celiac”, a review article by onathan S Alexander, PhD, et al from Department of Molecular and Cellular Physiology, Louisiana State University, School of Medicine, United States; (2) “Glucagon-like peptide-2 modulates the nitrergic neurotransmission in strips from the mouse gastric fundus”, a basic study by Maria Caterina Baccari, PhD, Associate Professor, et al from  Department of Experimental and Clinical Medicine, Section of Physiology, University of Florence, Italy; and (3) “Chronic opioids in gastroparesis: Relationship with gastrointestinal symptoms, healthcare utilization and employment”, an Observational Study by Henry P Parkman, MD, Professor, et al from Department of Gastroenterology, Temple University Hospital, United States, etc. We invite you to peruse all 16 articles in this issue, as they present the latest research progress/findings and provide insightful comments in gastroenterology and hepatology that will guide basic research and clinical practice in these fields.

Figure 1 The cover of the issue. Editorial board member of World Journal of Gastroenterology , Marcos V Perini, MD, MSc, PhD, Senior Lecturer, Department of Surgery, University of Melbourne, Melbourne, Victoria 3084, Australia

We encourage gastroenterologists and hepatologists worldwide to submit manuscripts to the WJG describing their original basic or clinical research findings that are of high academic value and which report new diagnostic techniques or summarize their treatment experiences.

We invited the readers to download and read the E-Journal of this issue.