Josué Aliaga Ramos, Service of Gastroenterology, Hospital José Agurto Tello-Chosica, Lima 15 150118, Peru
Josué Aliaga Ramos, Service of Gastroenterology, Clinica Madre Zoraida, Lima 15150118, Peru
Vitor Nunes Arantes, Endoscopy Unit, Alfa Institute of Gastroenterology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte 30130100, Minas Gerais, Brazil
Vitor Nunes Arantes, Endoscopy Unit, Hospital Mater Dei Contorno, Belo Horizonte 30110062, Minas Gerais, Brazil
Co-first authors: Josué Aliaga Ramos and Vitor Nunes Arantes.
Author contributions: Aliaga Ramos J and Arantes VN designed this study, performed the research and project administration, wrote the original and final drafts, and made equal contributions to this manuscript as co-first authors; All authors approved the final manuscript. Both authors contributed equally.
AI contribution statement: No AI usage for manuscript preparation.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Corresponding author: Vitor Nunes Arantes, MD, PhD, Adjunct Associate Professor, Chief, Endoscopy Unit, Alfa Institute of Gastroenterology, School of Medicine, Federal University of Minas Gerais, Av Professor Alfredo Balena 110, Belo Horizonte 30130100, Minas Gerais, Brazil. arantesvitor@hotmail.com
Received: April 20, 2026 Revised: May 21, 2026 Accepted: June 10, 2026 Published online: September 8, 2026 Processing time: 140 Days and 1.9 Hours
Core Tip
Core Tip: Colorectal endoscopic submucosal dissection (ESD) is an established organ-preserving treatment for selected superficial colorectal neoplasms, particularly early colorectal cancer with suspected superficial submucosal invasion. International guidelines recognize ESD as the preferred technique when en bloc resection is required for accurate histopathological evaluation and curative treatment. Compared with endoscopic mucosal resection, ESD achieves higher en bloc and complete resection rates, improving assessment of invasion depth and resection margins. In appropriately selected lesions, colorectal ESD provides favorable long-term oncologic outcomes comparable to surgery while preserving the native organ through a minimally invasive approach.
