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Saleh AI, Rabie AH, ElSayyad SE, Takieldeen AE, Khalifa F. An optimized ensemble grey wolf-based pipeline for monkeypox diagnosis. Sci Rep 2025; 15:3819. [PMID: 39885245 PMCID: PMC11782528 DOI: 10.1038/s41598-025-87455-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/28/2024] [Accepted: 01/20/2025] [Indexed: 02/01/2025] Open
Abstract
As the world recovered from the coronavirus, the emergence of the monkeypox virus signaled a potential new pandemic, highlighting the need for faster and more efficient diagnostic methods. This study introduces a hybrid architecture for automatic monkeypox diagnosis by leveraging a modified grey wolf optimization model for effective feature selection and weighting. Additionally, the system uses an ensemble of classifiers, incorporating confusion based voting scheme to combine salient data features. Evaluation on public data sets, at various of training samples percentages, showed that the proposed strategy achieves promising performance. Namely, the system yielded an overall accuracy of 98.91% with testing run time of 5.5 seconds, while using machine classifiers with small number of hyper-parameters. Additional experimental comparison reveals superior performance of the proposed system over literature approaches using various metrics. Statistical analysis also confirmed that the proposed AMDS outperformed other models after running 50 times. Finally, the generalizability of the proposed model is evaluated by testing its performance on external data sets for monkeypox and COVID-19. Our model achieved an overall diagnostic accuracy of 98.00% and 99.00% on external COVID and monkeypox data sets, respectively.
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Affiliation(s)
- Ahmed I Saleh
- Computers and Control Systems Engineering Department, Faculty of Engineering, Mansoura University, Mansoura, 35516, Egypt
| | - Asmaa H Rabie
- Computers and Control Systems Engineering Department, Faculty of Engineering, Mansoura University, Mansoura, 35516, Egypt
| | - Shimaa E ElSayyad
- Computers and Control Systems Engineering Department, Faculty of Engineering, Mansoura University, Mansoura, 35516, Egypt
- Communications and Computers Engineering Department, MISR Higher Institute for Engineering and Technology, Mansoura, 35516, Egypt
| | - Ali E Takieldeen
- Faculty of Artificial Intelligence, Delta University for Science and Technology, Gamasa, 35712, Egypt
| | - Fahmi Khalifa
- Electronics and Communication Engineering Department, Mansoura University, Mansoura, 35516, Egypt.
- Department of Electrical and Computer Engineering, Morgan State University, Baltimore, MD, 21251, USA.
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Yan HJ, Zhao JS, Zuo HD, Zhang JJ, Deng ZQ, Yang C, Luo X, Wan JX, Zheng XY, Chen WY, Li SP, Tian D. Dual-Region Computed Tomography Radiomics-Based Machine Learning Predicts Subcarinal Lymph Node Metastasis in Patients with Non-small Cell Lung Cancer. Ann Surg Oncol 2024; 31:5011-5020. [PMID: 38520581 DOI: 10.1245/s10434-024-15197-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/04/2024] [Accepted: 03/04/2024] [Indexed: 03/25/2024]
Abstract
BACKGROUND Noninvasively and accurately predicting subcarinal lymph node metastasis (SLNM) for patients with non-small cell lung cancer (NSCLC) remains challenging. This study was designed to develop and validate a tumor and subcarinal lymph nodes (tumor-SLNs) dual-region computed tomography (CT) radiomics model for predicting SLNM in NSCLC. METHODS This retrospective study included NSCLC patients who underwent lung resection and SLNs dissection between January 2017 and December 2020. The radiomic features of the tumor and SLNs were extracted from preoperative CT, respectively. Ninety machine learning (ML) models were developed based on tumor region, SLNs region, and tumor-SLNs dual-region. The model performance was assessed by the area under the curve (AUC) and validated internally by fivefold cross-validation. RESULTS In total, 202 patients were included in this study. ML models based on dual-region radiomics showed good performance for SLNM prediction, with a median AUC of 0.794 (range, 0.686-0.880), which was superior to those of models based on tumor region (median AUC, 0.746; range, 0.630-0.811) and SLNs region (median AUC, 0.700; range, 0.610-0.842). The ML model, which is developed by using the naive Bayes algorithm and dual-region features, had the highest AUC of 0.880 (range of cross-validation, 0.825-0.937) among all ML models. The optimal logistic regression model was inferior to the optimal ML model for predicting SLNM, with an AUC of 0.727. CONCLUSIONS The CT radiomics showed the potential for accurately predicting SLNM in NSCLC patients. The ML model with dual-region radiomic features has better performance than the logistic regression or single-region models.
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Affiliation(s)
- Hao-Ji Yan
- Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China
- Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan
| | - Jia-Sheng Zhao
- College of Clinical Medicine, North Sichuan Medical College, Nanchong, China
| | - Hou-Dong Zuo
- Medical Imaging Key Laboratory of Sichuan Province, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Jun-Jie Zhang
- College of Medical Imaging, North Sichuan Medical College, Nanchong, China
| | - Zhi-Qiang Deng
- College of Medical Imaging, North Sichuan Medical College, Nanchong, China
| | - Chen Yang
- College of Medical Imaging, North Sichuan Medical College, Nanchong, China
| | - Xi Luo
- College of Clinical Medicine, North Sichuan Medical College, Nanchong, China
| | - Jia-Xin Wan
- College of Clinical Medicine, North Sichuan Medical College, Nanchong, China
| | - Xiang-Yun Zheng
- Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China
| | - Wei-Yang Chen
- Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China
| | - Su-Ping Li
- Department of Nuclear Medicine, Affiliated Hospital of North Sichuan Medical College, North Sichuan Medical College, Nanchong, China.
| | - Dong Tian
- Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.
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Ma F, Wang S, Guo Y, Dai C, Meng J. Image segmentation of mouse eye in vivo with optical coherence tomography based on Bayesian classification. BIOMED ENG-BIOMED TE 2024; 69:307-315. [PMID: 38178615 DOI: 10.1515/bmt-2023-0266] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/16/2023] [Accepted: 12/22/2023] [Indexed: 01/06/2024]
Abstract
OBJECTIVES Optical coherence tomography (OCT) is a new imaging technology that uses an optical analog of ultrasound imaging for biological tissues. Image segmentation plays an important role in dealing with quantitative analysis of medical images. METHODS We have proposed a novel framework to deal with the low intensity problem, based on the labeled patches and Bayesian classification (LPBC) model. The proposed method includes training and testing phases. During the training phase, firstly, we manually select the sub-images of background and Region of Interest (ROI) from the training image, and then extract features by patches. Finally, we train the Bayesian model with the features. The segmentation threshold of each patch is computed by the learned Bayesian model. RESULTS In addition, we have collected a new dataset of mouse eyes in vivo with OCT, named MEVOCT, which can be found at URL https://17861318579.github.io/LPBC. MEVOCT consists of 20 high-resolution images. The resolution of every image is 2048 × 2048 pixels. CONCLUSIONS The experimental results demonstrate the effectiveness of the LPBC method on the new MEVOCT dataset. The ROI segmentation is of great importance for the distortion correction.
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Affiliation(s)
- Fei Ma
- School of Computer Science, Qufu Normal University, Rizhao, Shandong, China
| | - Shengbo Wang
- School of Computer Science, Qufu Normal University, Rizhao, Shandong, China
| | - Yanfei Guo
- School of Computer Science, Qufu Normal University, Rizhao, Shandong, China
| | - Cuixia Dai
- Department of College Science, Shanghai Institute of Technology, Shanghai, Shanghai, China
| | - Jing Meng
- School of Computer Science, Qufu Normal University, Rizhao, Shandong, China
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Ju H, Cui Y, Su Q, Juan L, Manavalan B. CODENET: A deep learning model for COVID-19 detection. Comput Biol Med 2024; 171:108229. [PMID: 38447500 DOI: 10.1016/j.compbiomed.2024.108229] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2023] [Revised: 02/20/2024] [Accepted: 02/25/2024] [Indexed: 03/08/2024]
Abstract
Conventional COVID-19 testing methods have some flaws: they are expensive and time-consuming. Chest X-ray (CXR) diagnostic approaches can alleviate these flaws to some extent. However, there is no accurate and practical automatic diagnostic framework with good interpretability. The application of artificial intelligence (AI) technology to medical radiography can help to accurately detect the disease, reduce the burden on healthcare organizations, and provide good interpretability. Therefore, this study proposes a new deep neural network (CNN) based on CXR for COVID-19 diagnosis - CodeNet. This method uses contrastive learning to make full use of latent image data to enhance the model's ability to extract features and generalize across different data domains. On the evaluation dataset, the proposed method achieves an accuracy as high as 94.20%, outperforming several other existing methods used for comparison. Ablation studies validate the efficacy of the proposed method, while interpretability analysis shows that the method can effectively guide clinical professionals. This work demonstrates the superior detection performance of a CNN using contrastive learning techniques on CXR images, paving the way for computer vision and artificial intelligence technologies to leverage massive medical data for disease diagnosis.
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Affiliation(s)
- Hong Ju
- Heilongjiang Agricultural Engineering Vocational College, China
| | - Yanyan Cui
- Beidahuang Industry Group General Hospital, Harbin, China
| | - Qiaosen Su
- Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, 16419, Gyeonggi-do, Republic of Korea
| | - Liran Juan
- School of Life Science and Technology, Harbin Institute of Technology, Harbin, 150001, China.
| | - Balachandran Manavalan
- Department of Integrative Biotechnology, College of Biotechnology and Bioengineering, Sungkyunkwan University, Suwon, 16419, Gyeonggi-do, Republic of Korea.
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Zhunissova U, Dzierżak R, Omiotek Z, Lytvynenko V. A Novel COVID-19 Diagnosis Approach Utilizing a Comprehensive Set of Diagnostic Information (CSDI). J Clin Med 2023; 12:6912. [PMID: 37959377 PMCID: PMC10649663 DOI: 10.3390/jcm12216912] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/04/2023] [Revised: 10/19/2023] [Accepted: 10/31/2023] [Indexed: 11/15/2023] Open
Abstract
The aim of the study was to develop a computerized method for distinguishing COVID-19-affected cases from cases of pneumonia. This task continues to be a real challenge in the practice of diagnosing COVID-19 disease. In the study, a new approach was proposed, using a comprehensive set of diagnostic information (CSDI) including, among other things, medical history, demographic data, signs and symptoms of the disease, and laboratory results. These data have the advantage of being much more reliable compared with data based on a single source of information, such as radiological imaging. On this basis, a comprehensive process of building predictive models was carried out, including such steps as data preprocessing, feature selection, training, and evaluation of classification models. During the study, 9 different methods for feature selection were used, while the grid search method and 12 popular classification algorithms were employed to build classification models. The most effective model achieved a classification accuracy (ACC) of 85%, a sensitivity (TPR) equal to 83%, and a specificity (TNR) of 88%. The model was built using the random forest method with 15 features selected using the recursive feature elimination selection method. The results provide an opportunity to build a computer system to assist the physician in the diagnosis of the COVID-19 disease.
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Affiliation(s)
- Ulzhalgas Zhunissova
- Department of Biostatistics, Bioinformatics and Information Technologies, Astana Medical University, Beibitshilik Street 49A, Astana 010000, Kazakhstan
| | - Róża Dzierżak
- Faculty of Electrical Engineering and Computer Science, Lublin University of Technology, Nadbystrzycka 38 A, 20-618 Lublin, Poland
| | - Zbigniew Omiotek
- Faculty of Electrical Engineering and Computer Science, Lublin University of Technology, Nadbystrzycka 38 A, 20-618 Lublin, Poland
| | - Volodymyr Lytvynenko
- Department of Informatics and Computer Science, Kherson National Technical University, Beryslavs’ke Hwy, 24, 730082 Kherson, Kherson Oblast, Ukraine
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Rabie AH, Mohamed AM, Abo-Elsoud MA, Saleh AI. A new Covid-19 diagnosis strategy using a modified KNN classifier. Neural Comput Appl 2023; 35:1-25. [PMID: 37362572 PMCID: PMC10153048 DOI: 10.1007/s00521-023-08588-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/09/2022] [Accepted: 04/05/2023] [Indexed: 06/28/2023]
Abstract
Covid-19 is a very dangerous disease as a result of the rapid and unprecedented spread of any previous disease. It is truly a crisis that threatens the world since its first appearance in December 2019 until our time. Due to the lack of a vaccine that has proved sufficiently effective so far, the rapid and more accurate diagnosis of this disease is extremely necessary to enable the medical staff to identify infected cases and isolate them from the rest to prevent further loss of life. In this paper, Covid-19 diagnostic strategy (CDS) as a new classification strategy that consists of two basic phases: Feature selection phase (FSP) and diagnosis phase (DP) has been introduced. During the first phase called FSP, the best set of features in laboratory test findings for Covid-19 patients will be selected using enhanced gray wolf optimization (EGWO). EGWO combines both types of selection techniques called wrapper and filter. Accordingly, EGWO includes two stages called filter stage (FS) and wrapper stage (WS). While FS uses many different filter methods, WS uses a wrapper method called binary gray wolf optimization (BGWO). The second phase called DP aims to give fast and more accurate diagnosis using a hybrid diagnosis methodology (HDM) based on the selected features from FSP. In fact, the HDM consists of two phases called weighting patient phase (WP2) and diagnostic patient phase (DP2). WP2 aims to calculate the belonging degree of each patient in the testing dataset to class category using naïve Bayes (NB) as a weight method. On the other hand, K-nearest neighbor (KNN) will be used in DP2 based on the weights of patients in the testing dataset as a new training dataset to give rapid and more accurate detection. The suggested CDS outperforms other strategies according to accuracy, precision, recall (or sensitivity) and F-measure calculations that are equal to 99%, 88%, 90% and 91%, respectively, as showed in experimental results.
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Affiliation(s)
- Asmaa H. Rabie
- Computers and Control Department Faculty of Engineering, Mansoura University, Mansoura, Egypt
| | - Alaa M. Mohamed
- Delta Higher Institute for Engineering and Technology, Talkha, Mansoura, Egypt
| | - M. A. Abo-Elsoud
- Electronics and Communication Department Faculty of Engineering, Mansoura University, Mansoura, Egypt
| | - Ahmed I. Saleh
- Computers and Control Department Faculty of Engineering, Mansoura University, Mansoura, Egypt
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7
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Yazdani A, Bigdeli SK, Zahmatkeshan M. Investigating the performance of machine learning algorithms in predicting the survival of COVID-19 patients: A cross section study of Iran. Health Sci Rep 2023; 6:e1212. [PMID: 37064314 PMCID: PMC10099201 DOI: 10.1002/hsr2.1212] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/10/2022] [Revised: 03/23/2023] [Accepted: 03/30/2023] [Indexed: 04/18/2023] Open
Abstract
Background and Aims Like early diagnosis, predicting the survival of patients with Coronavirus Disease 2019 (COVID-19) is of great importance. Survival prediction models help doctors be more cautious to treat the patients who are at high risk of dying because of medical conditions. This study aims to predict the survival of hospitalized patients with COVID-19 by comparing the accuracy of machine learning (ML) models. Methods It is a cross-sectional study which was performed in 2022 in Fasa city in Iran country. The research data set was extracted from the period February 18, 2020 to February 10, 2021, and contains 2442 hospitalized patients' records with 84 features. A comparison was made between the efficiency of five ML algorithms to predict survival, includes Naive Bayes (NB), K-nearest neighbors (KNN), random forest (RF), decision tree (DT), and multilayer perceptron (MLP). Modeling steps were done with Python language in the Anaconda Navigator 3 environment. Results Our findings show that NB algorithm had better performance than others with accuracy, precision, recall, F-score, and area under receiver operating characteristic curve of 97%, 96%, 96%, 96%, and 97%, respectively. Based on the analysis of factors affecting survival, heart disease, pulmonary diseases and blood related disease were the most important disease related to death. Conclusion The development of software systems based on NB will be effective to predict the survival of COVID-19 patients.
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Affiliation(s)
- Azita Yazdani
- Department of Health Information Management, School of Health Management and Information SciencesShiraz University of Medical SciencesShirazIran
- Clinical Education Research CenterShiraz University of Medical SciencesShirazIran
- Health Human Resources Research Center, School of Health Management and Information SciencesShiraz University of Medical SciencesShirazIran
| | - Somayeh Kianian Bigdeli
- Health Information Management Department, School of Allied Medical SciencesTehran University of Medical SciencesTehranIran
| | - Maryam Zahmatkeshan
- Noncommunicable Diseases Research CenterFasa University of Medical SciencesFasaIran
- School of Allied Medical SciencesFasa University of Medical SciencesFasaIran
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Robust Classification and Detection of Big Medical Data Using Advanced Parallel K-Means Clustering, YOLOv4, and Logistic Regression. Life (Basel) 2023; 13:life13030691. [PMID: 36983845 PMCID: PMC10056696 DOI: 10.3390/life13030691] [Citation(s) in RCA: 3] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/30/2023] [Revised: 02/24/2023] [Accepted: 02/28/2023] [Indexed: 03/08/2023] Open
Abstract
Big-medical-data classification and image detection are crucial tasks in the field of healthcare, as they can assist with diagnosis, treatment planning, and disease monitoring. Logistic regression and YOLOv4 are popular algorithms that can be used for these tasks. However, these techniques have limitations and performance issue with big medical data. In this study, we presented a robust approach for big-medical-data classification and image detection using logistic regression and YOLOv4, respectively. To improve the performance of these algorithms, we proposed the use of advanced parallel k-means pre-processing, a clustering technique that identified patterns and structures in the data. Additionally, we leveraged the acceleration capabilities of a neural engine processor to further enhance the speed and efficiency of our approach. We evaluated our approach on several large medical datasets and showed that it could accurately classify large amounts of medical data and detect medical images. Our results demonstrated that the combination of advanced parallel k-means pre-processing, and the neural engine processor resulted in a significant improvement in the performance of logistic regression and YOLOv4, making them more reliable for use in medical applications. This new approach offers a promising solution for medical data classification and image detection and may have significant implications for the field of healthcare.
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Cai C, Gou B, Khishe M, Mohammadi M, Rashidi S, Moradpour R, Mirjalili S. Improved deep convolutional neural networks using chimp optimization algorithm for Covid19 diagnosis from the X-ray images. EXPERT SYSTEMS WITH APPLICATIONS 2023; 213:119206. [PMID: 36348736 PMCID: PMC9633109 DOI: 10.1016/j.eswa.2022.119206] [Citation(s) in RCA: 20] [Impact Index Per Article: 10.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/12/2021] [Revised: 09/17/2022] [Accepted: 10/31/2022] [Indexed: 05/11/2023]
Abstract
Applying Deep Learning (DL) in radiological images (i.e., chest X-rays) is emerging because of the necessity of having accurate and fast COVID-19 detectors. Deep Convolutional Neural Networks (DCNN) have been typically used as robust COVID-19 positive case detectors in these approaches. Such DCCNs tend to utilize Gradient Descent-Based (GDB) algorithms as the last fully-connected layers' trainers. Although GDB training algorithms have simple structures and fast convergence rates for cases with large training samples, they suffer from the manual tuning of numerous parameters, getting stuck in local minima, large training samples set requirements, and inherently sequential procedures. It is exceedingly challenging to parallelize them with Graphics Processing Units (GPU). Consequently, the Chimp Optimization Algorithm (ChOA) is presented for training the DCNN's fully connected layers in light of the scarcity of a big COVID-19 training dataset and for the purpose of developing a fast COVID-19 detector with the capability of parallel implementation. In addition, two publicly accessible datasets termed COVID-Xray-5 k and COVIDetectioNet are used to benchmark the proposed detector known as DCCN-Chimp. In order to make a fair comparison, two structures are proposed: i-6c-2 s-12c-2 s and i-8c-2 s-16c-2 s, all of which have had their hyperparameters fine-tuned. The outcomes are evaluated in comparison to standard DCNN, Hybrid DCNN plus Genetic Algorithm (DCNN-GA), and Matched Subspace classifier with Adaptive Dictionaries (MSAD). Due to the large variation in results, we employ a weighted average of the ensemble of ten trained DCNN-ChOA, with the validation accuracy of the weights being used to determine the final weights. The validation accuracy for the mixed ensemble DCNN-ChOA is 99.11%. LeNet-5 DCNN's ensemble detection accuracy on COVID-19 is 84.58%. Comparatively, the suggested DCNN-ChOA yields over 99.11% accurate detection with a false alarm rate of less than 0.89%. The outcomes show that the DCCN-Chimp can deliver noticeably superior results than the comparable detectors. The Class Activation Map (CAM) is another tool used in this study to identify probable COVID-19-infected areas. Results show that highlighted regions are completely connected with clinical outcomes, which has been verified by experts.
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Affiliation(s)
- Chengfeng Cai
- School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China
| | - Bingchen Gou
- School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China
| | - Mohammad Khishe
- Departement of Electrical Engineering, Imam Khomeini Marine Science University, Nowshahr, Iran
| | - Mokhtar Mohammadi
- Department of Information Technology, College of Engineering and Computer Science, Lebanese French University, Kurdistan Region, Iraq
| | - Shima Rashidi
- Department of Computer Science, College of Science and Technology, University of Human Development, Sulaymaniyah, Kurdistan Region, Iraq
| | - Reza Moradpour
- Departement of Electrical Engineering, Imam Khomeini Marine Science University, Nowshahr, Iran
| | - Seyedali Mirjalili
- Centre for Artificial Intelligence Research and Optimization, Torrens University, Australia
- University Research and Innovation Center, Obuda University, 1034 Budapest, Hungary
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10
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Cai C, Gou B, Khishe M, Mohammadi M, Rashidi S, Moradpour R, Mirjalili S. Improved deep convolutional neural networks using chimp optimization algorithm for Covid19 diagnosis from the X-ray images. EXPERT SYSTEMS WITH APPLICATIONS 2023; 213:119206. [PMID: 36348736 DOI: 10.1016/j.eswa.2020.113338] [Citation(s) in RCA: 199] [Impact Index Per Article: 99.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/12/2021] [Revised: 09/17/2022] [Accepted: 10/31/2022] [Indexed: 05/25/2023]
Abstract
Applying Deep Learning (DL) in radiological images (i.e., chest X-rays) is emerging because of the necessity of having accurate and fast COVID-19 detectors. Deep Convolutional Neural Networks (DCNN) have been typically used as robust COVID-19 positive case detectors in these approaches. Such DCCNs tend to utilize Gradient Descent-Based (GDB) algorithms as the last fully-connected layers' trainers. Although GDB training algorithms have simple structures and fast convergence rates for cases with large training samples, they suffer from the manual tuning of numerous parameters, getting stuck in local minima, large training samples set requirements, and inherently sequential procedures. It is exceedingly challenging to parallelize them with Graphics Processing Units (GPU). Consequently, the Chimp Optimization Algorithm (ChOA) is presented for training the DCNN's fully connected layers in light of the scarcity of a big COVID-19 training dataset and for the purpose of developing a fast COVID-19 detector with the capability of parallel implementation. In addition, two publicly accessible datasets termed COVID-Xray-5 k and COVIDetectioNet are used to benchmark the proposed detector known as DCCN-Chimp. In order to make a fair comparison, two structures are proposed: i-6c-2 s-12c-2 s and i-8c-2 s-16c-2 s, all of which have had their hyperparameters fine-tuned. The outcomes are evaluated in comparison to standard DCNN, Hybrid DCNN plus Genetic Algorithm (DCNN-GA), and Matched Subspace classifier with Adaptive Dictionaries (MSAD). Due to the large variation in results, we employ a weighted average of the ensemble of ten trained DCNN-ChOA, with the validation accuracy of the weights being used to determine the final weights. The validation accuracy for the mixed ensemble DCNN-ChOA is 99.11%. LeNet-5 DCNN's ensemble detection accuracy on COVID-19 is 84.58%. Comparatively, the suggested DCNN-ChOA yields over 99.11% accurate detection with a false alarm rate of less than 0.89%. The outcomes show that the DCCN-Chimp can deliver noticeably superior results than the comparable detectors. The Class Activation Map (CAM) is another tool used in this study to identify probable COVID-19-infected areas. Results show that highlighted regions are completely connected with clinical outcomes, which has been verified by experts.
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Affiliation(s)
- Chengfeng Cai
- School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China
| | - Bingchen Gou
- School of Mechanical Engineering, Northwestern Polytechnical University, Xi'an 710072, China
| | - Mohammad Khishe
- Departement of Electrical Engineering, Imam Khomeini Marine Science University, Nowshahr, Iran
| | - Mokhtar Mohammadi
- Department of Information Technology, College of Engineering and Computer Science, Lebanese French University, Kurdistan Region, Iraq
| | - Shima Rashidi
- Department of Computer Science, College of Science and Technology, University of Human Development, Sulaymaniyah, Kurdistan Region, Iraq
| | - Reza Moradpour
- Departement of Electrical Engineering, Imam Khomeini Marine Science University, Nowshahr, Iran
| | - Seyedali Mirjalili
- Centre for Artificial Intelligence Research and Optimization, Torrens University, Australia
- University Research and Innovation Center, Obuda University, 1034 Budapest, Hungary
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11
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Innovation in Hyperinsulinemia Diagnostics with ANN-L( atin square) Models. Diagnostics (Basel) 2023; 13:diagnostics13040798. [PMID: 36832286 PMCID: PMC9955502 DOI: 10.3390/diagnostics13040798] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/10/2023] [Revised: 02/11/2023] [Accepted: 02/12/2023] [Indexed: 02/22/2023] Open
Abstract
Hyperinsulinemia is a condition characterized by excessively high levels of insulin in the bloodstream. It can exist for many years without any symptomatology. The research presented in this paper was conducted from 2019 to 2022 in cooperation with a health center in Serbia as a large cross-sectional observational study of adolescents of both genders using datasets collected from the field. Previously used analytical approaches of integrated and relevant clinical, hematological, biochemical, and other variables could not identify potential risk factors for developing hyperinsulinemia. This paper aims to present several different models using machine learning (ML) algorithms such as naive Bayes, decision tree, and random forest and compare them with a new methodology constructed based on artificial neural networks using Taguchi's orthogonal vector plans (ANN-L), a special extraction of Latin squares. Furthermore, the experimental part of this study showed that ANN-L models achieved an accuracy of 99.5% with less than seven iterations performed. Furthermore, the study provides valuable insights into the share of each risk factor contributing to the occurrence of hyperinsulinemia in adolescents, which is crucial for more precise and straightforward medical diagnoses. Preventing the risk of hyperinsulinemia in this age group is crucial for the well-being of the adolescents and society as a whole.
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Saleem K, Saleem M, Ahmad RZ, Javed AR, Alazab M, Gadekallu TR, Suleman A. Situation-Aware BDI Reasoning to Detect Early Symptoms of Covid 19 Using Smartwatch. IEEE SENSORS JOURNAL 2023; 23:898-905. [PMID: 36913222 PMCID: PMC9983688 DOI: 10.1109/jsen.2022.3156819] [Citation(s) in RCA: 20] [Impact Index Per Article: 10.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/27/2022] [Accepted: 02/28/2022] [Indexed: 05/09/2023]
Abstract
Ambient intelligence plays a crucial role in healthcare situations. It provides a certain way to deal with emergencies to provide the essential resources such as nearest hospitals and emergency stations promptly to avoid deaths. Since the outbreak of Covid-19, several artificial intelligence techniques have been used. However, situation awareness is a key aspect to handling any pandemic situation. The situation-awareness approach gives patients a routine life where they are continuously monitored by caregivers through wearable sensors and alert the practitioners in case of any patient emergency. Therefore, in this paper, we propose a situation-aware mechanism to detect Covid-19 systems early and alert the user to be self-aware regarding the situation to take precautions if the situation seems unlikely to be normal. We provide Belief-Desire-Intention intelligent reasoning mechanism for the system to analyze the situation after acquiring the data from the wearable sensors and alert the user according to their environment. We use the case study for further demonstration of our proposed framework. We model the proposed system by temporal logic and map the system illustration into a simulation tool called NetLogo to determine the results of the proposed system.
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Affiliation(s)
- Kiran Saleem
- School of SoftwareDalian University of TechnologyDalian116024China
| | - Misbah Saleem
- Institute of Diet and Nutritional Science, University of LahoreLahore54590Pakistan
| | | | | | - Mamoun Alazab
- College of EngineeringIT and Environment, Charles Darwin UniversityDarwinNT0815Australia
| | | | - Ahmad Suleman
- Center of Excellence in Solid State PhysicsUniversity of PunjabLahore05422Pakistan
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13
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Shaban WM. Insight into breast cancer detection: new hybrid feature selection method. Neural Comput Appl 2022. [DOI: 10.1007/s00521-022-08062-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/05/2022]
Abstract
AbstractBreast cancer, which is also the leading cause of death among women, is one of the most common forms of the disease that affects females all over the world. The discovery of breast cancer at an early stage is extremely important because it allows selecting appropriate treatment protocol and thus, stops the development of cancer cells. In this paper, a new patients detection strategy has been presented to identify patients with the disease earlier. The proposed strategy composes of two parts which are data preprocessing phase and patient detection phase (PDP). The purpose of this study is to introduce a feature selection methodology for determining the most efficient and significant features for identifying breast cancer patients. This method is known as new hybrid feature selection method (NHFSM). NHFSM is made up of two modules which are quick selection module that uses information gain, and feature selection module that uses hybrid bat algorithm and particle swarm optimization. Consequently, NHFSM is a hybrid method that combines the advantages of bat algorithm and particle swarm optimization based on filter method to eliminate many drawbacks such as being stuck in a local optimal solution and having unbalanced exploitation. The preprocessed data are then used during PDP in order to enable a quick and accurate detection of patients. Based on experimental results, the proposed NHFSM improves the efficiency of patients’ classification in comparison with state-of-the-art feature selection approaches by roughly 0.97, 0.76, 0.75, and 0.716 in terms of accuracy, precision, sensitivity/recall, and F-measure. In contrast, it has the lowest error rate value of 0.03.
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14
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Lanjewar MG, Shaikh AY, Parab J. Cloud-based COVID-19 disease prediction system from X-Ray images using convolutional neural network on smartphone. MULTIMEDIA TOOLS AND APPLICATIONS 2022; 82:1-30. [PMID: 36467434 PMCID: PMC9684956 DOI: 10.1007/s11042-022-14232-w] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 05/05/2022] [Revised: 11/01/2022] [Accepted: 11/04/2022] [Indexed: 06/17/2023]
Abstract
COVID-19 has engulfed over 200 nations through human-to-human transmission, either directly or indirectly. Reverse Transcription-polymerase Chain Reaction (RT-PCR) has been endorsed as a standard COVID-19 diagnostic procedure but has caveats such as low sensitivity, the need for a skilled workforce, and is time-consuming. Coronaviruses show significant manifestation in Chest X-Ray (CX-Ray) images and, thus, can be a viable option for an alternate COVID-19 diagnostic strategy. An automatic COVID-19 detection system can be developed to detect the disease, thus reducing strain on the healthcare system. This paper discusses a real-time Convolutional Neural Network (CNN) based system for COVID-19 illness prediction from CX-Ray images on the cloud. The implemented CNN model displays exemplary results, with training accuracy being 99.94% and validation accuracy reaching 98.81%. The confusion matrix was utilized to assess the models' outcome and achieved 99% precision, 98% recall, 99% F1 score, 100% training area under the curve (AUC) and 98.3% validation AUC. The same CX-Ray dataset was also employed to predict the COVID-19 disease with deep Convolution Neural Networks (DCNN), such as ResNet50, VGG19, InceptonV3, and Xception. The prediction outcome demonstrated that the present CNN was more capable than the DCNN models. The efficient CNN model was deployed to the Platform as a Service (PaaS) cloud.
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Affiliation(s)
- Madhusudan G. Lanjewar
- School of Physical and Applied Sciences, Goa University, Taleigao Plateau, Goa, 403206 India
| | - Arman Yusuf Shaikh
- School of Physical and Applied Sciences, Goa University, Taleigao Plateau, Goa, 403206 India
| | - Jivan Parab
- School of Physical and Applied Sciences, Goa University, Taleigao Plateau, Goa, 403206 India
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15
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Yazdani A, Zahmatkeshan M, Ravangard R, Sharifian R, Shirdeli M. Supervised Machine Learning Approach to COVID-19 Detection Based on Clinical Data. Med J Islam Repub Iran 2022; 36:110. [PMID: 36447543 PMCID: PMC9700415 DOI: 10.47176/mjiri.36.110] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/07/2021] [Indexed: 09/10/2024] Open
Abstract
Background: The new coronavirus has been spreading since the beginning of 2020, and many efforts have been made to develop vaccines to help patients recover. It is now clear that the world needs a rapid solution to curb the spread of COVID-19 worldwide with non-clinical approaches such as artificial intelligence techniques. These approaches can be effective in reducing the burden on the health care system to provide the best possible way to diagnose the COVID-19 epidemic. This study was conducted to use Machine Learning (ML) algorithms for the early detection of COVID-19 in patients. Methods: This retrospective study used data from hospitals affiliated with Shiraz University of Medical Sciences in Iran. This dataset was collected in the period March to October 2020 andcontained 10055 cases with 63 features. We selected and compared six algorithms: C4.5, support vector machine (SVM), Naive Bayes, logistic Regression (LR), Random Forest, and K-Nearest Neighbor algorithm using Rapid Miner software. The performance of algorithms was measured using evaluation metrics, such as precision, recall, accuracy, and f-measure. Results: The results of the study show that among the various used classification methods in the diagnosis of coronavirus, SVM (93.41% accuracy) and C4.5 (91.87% accuracy) achieved the highest performance. According to the C4.5 decision tree, "contact with a person who has COVID-19" was considered the most important diagnostic criterion based on the Gini index. Conclusion: We found that ML approaches enable a reasonable level of accuracy in the diagnosis of COVID-19.
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Affiliation(s)
- Azita Yazdani
- Department of Health Information Management, Clinical Education Research Center, Health Human Resources Research Center, School of Health Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Maryam Zahmatkeshan
- Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
- School of Allied Medical Sciences, Fasa University of Medical Sciences, Fasa, Iran
| | - Ramin Ravangard
- Department of Health Services Management, Health Human Resources Research Center, School of Health Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Roxana Sharifian
- Department of Health Information Management, Health Human Resources Research Center, School of Health Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
| | - Mohammad Shirdeli
- Department of Health Information Management, Student Research Committee, Health Human Resources Research Center, School of Health Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
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16
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Li DL, Zhang L, Yan HJ, Zheng YB, Guo XG, Tang SJ, Hu HY, Yan H, Qin C, Zhang J, Guo HY, Zhou HN, Tian D. Machine learning models predict lymph node metastasis in patients with stage T1-T2 esophageal squamous cell carcinoma. Front Oncol 2022; 12:986358. [PMID: 36158684 PMCID: PMC9496653 DOI: 10.3389/fonc.2022.986358] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/05/2022] [Accepted: 08/17/2022] [Indexed: 11/21/2022] Open
Abstract
Background For patients with stage T1-T2 esophageal squamous cell carcinoma (ESCC), accurately predicting lymph node metastasis (LNM) remains challenging. We aimed to investigate the performance of machine learning (ML) models for predicting LNM in patients with stage T1-T2 ESCC. Methods Patients with T1-T2 ESCC at three centers between January 2014 and December 2019 were included in this retrospective study and divided into training and external test sets. All patients underwent esophagectomy and were pathologically examined to determine the LNM status. Thirty-six ML models were developed using six modeling algorithms and six feature selection techniques. The optimal model was determined by the bootstrap method. An external test set was used to further assess the model’s generalizability and effectiveness. To evaluate prediction performance, the area under the receiver operating characteristic curve (AUC) was applied. Results Of the 1097 included patients, 294 (26.8%) had LNM. The ML models based on clinical features showed good predictive performance for LNM status, with a median bootstrapped AUC of 0.659 (range: 0.592, 0.715). The optimal model using the naive Bayes algorithm with feature selection by determination coefficient had the highest AUC of 0.715 (95% CI: 0.671, 0.763). In the external test set, the optimal ML model achieved an AUC of 0.752 (95% CI: 0.674, 0.829), which was superior to that of T stage (0.624, 95% CI: 0.547, 0.701). Conclusions ML models provide good LNM prediction value for stage T1-T2 ESCC patients, and the naive Bayes algorithm with feature selection by determination coefficient performed best.
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Affiliation(s)
- Dong-lin Li
- Department of Thoracic Surgery, Suining Central Hospital, Sunning, China
| | - Lin Zhang
- Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Hao-ji Yan
- Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China
- Academician (Expert) Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
| | - Yin-bin Zheng
- Department of Thoracic Surgery, Nanchong Central Hospital, Nanchong, China
| | - Xiao-guang Guo
- Department of Pathology, Nanchong Central Hospital, Nanchong, China
| | - Sheng-jie Tang
- Department of Thoracic Surgery, Suining Central Hospital, Sunning, China
| | - Hai-yang Hu
- Department of Thoracic Surgery, Suining Central Hospital, Sunning, China
| | - Hang Yan
- Department of Thoracic Surgery, Suining Central Hospital, Sunning, China
| | - Chao Qin
- Department of Thoracic Surgery, Suining Central Hospital, Sunning, China
| | - Jun Zhang
- Department of Thoracic Surgery, Suining Central Hospital, Sunning, China
| | - Hai-yang Guo
- Department of Thoracic Surgery, Suining Central Hospital, Sunning, China
| | - Hai-ning Zhou
- Department of Thoracic Surgery, Suining Central Hospital, Sunning, China
- *Correspondence: Hai-ning Zhou, ; Dong Tian,
| | - Dong Tian
- Department of Thoracic Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
- Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China
- Academician (Expert) Workstation, Affiliated Hospital of North Sichuan Medical College, Nanchong, China
- *Correspondence: Hai-ning Zhou, ; Dong Tian,
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Rabie AH, Mansour NA, Saleh AI, Takieldeen AE. Expecting individuals' body reaction to Covid-19 based on statistical Naïve Bayes technique. PATTERN RECOGNITION 2022; 128:108693. [PMID: 35400761 PMCID: PMC8983097 DOI: 10.1016/j.patcog.2022.108693] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 07/15/2021] [Revised: 02/01/2022] [Accepted: 04/03/2022] [Indexed: 06/14/2023]
Abstract
Covid-19, what a strange, unpredictable mutated virus. It has baffled many scientists, as no firm rule has yet been reached to predict the effect that the virus can inflict on people if they are infected with it. Recently, many researches have been introduced for diagnosing Covid-19; however, none of them pay attention to predict the effect of the virus on the person's body if the infection occurs but before the infection really takes place. Predicting the extent to which people will be affected if they are infected with the virus allows for some drastic precautions to be taken for those who will suffer from serious complications, while allowing some freedom for those who expect not to be affected badly. This paper introduces Covid-19 Prudential Expectation Strategy (CPES) as a new strategy for predicting the behavior of the person's body if he has been infected with Covid-19. The CPES composes of three phases called Outlier Rejection Phase (ORP), Feature Selection Phase (FSP), and Classification Phase (CP). For enhancing the classification accuracy in CP, CPES employs two proposed techniques for outlier rejection in ORP and feature selection in FSP, which are called Hybrid Outlier Rejection (HOR) method and Improved Binary Genetic Algorithm (IBGA) method respectively. In ORP, HOR rejects outliers in the training data using a hybrid method that combines standard division and Binary Gray Wolf Optimization (BGWO) method. On the other hand, in FSP, IBGA as a hybrid method selects the most useful features for the prediction process. IBGA includes Fisher Score (FScore) as a filter method to quickly select the features and BGA as a wrapper method to accurately select the features based on the average accuracy value from several classification models as a fitness function to guarantee the efficiency of the selected subset of features with any classifier. In CP, CPES has the ability to classify people based on their bodies' reaction to Covid-19 infection, which is built upon a proposed Statistical Naïve Bayes (SNB) classifier after performing the previous two phases. CPES has been compared against recent related strategies in terms of accuracy, error, recall, precision, and run-time using Covid-19 dataset [1]. This dataset contains routine blood tests collected from people before and after their infection with covid-19 through a Web-based form created by us. CPES outperforms the competing methods in experimental results because it provides the best results with values of 0.87, 0.13, 0.84, and 0.79 for accuracy, error, precision, and recall.
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Affiliation(s)
- Asmaa H Rabie
- Computers and Control Dept. faculty of engineering Mansoura University, Mansoura, Egypt
| | - Nehal A Mansour
- Nile Higher Institute for Engineering and Technology, Artificial intelligence Lab., Mansoura, Egypt
| | - Ahmed I Saleh
- Computers and Control Dept. faculty of engineering Mansoura University, Mansoura, Egypt
| | - Ali E Takieldeen
- IEEE Senior Member, Faculty of Artificial Intelligence, Delta University For Science and Technology, Egypt
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18
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Xie J, Feng S, Qu Z. Adoption of Dexmedetomidine in Different Doses at Different Timing in Perioperative Patients. BIOMED RESEARCH INTERNATIONAL 2022; 2022:4008941. [PMID: 35872874 PMCID: PMC9307348 DOI: 10.1155/2022/4008941] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 03/18/2022] [Revised: 04/15/2022] [Accepted: 05/03/2022] [Indexed: 11/20/2022]
Abstract
Dexmedetomidine (Dex) is an alpha-2 agonist used for sedation during various procedures. Dex activates 2-adrenoceptors, and causes the decrease of sympathetic tone, with attenuation of the neuroendocrine and hemodynamic responses to anesthesia and surgery; it reduces anesthetic and opioid requirements; and causes sedation and analgesia. OBJECTIVE it was to compare the perioperative effects of different doses of Dex at different timing in patients using Dex during the perioperative period adopting a medical data classification algorithm based on optimized semi-supervised collaborative training (Tri-training). METHODS 495 patients requiring surgical treatment in Xingtai People's Hospital were randomly selected as the study subjects. The patients were divided into group A (used before induction), group B (used during induction), and group C (used after induction) according to different induction timing, with 165 cases in each group. Then, groups A, B, and C were divided into groups A1, B1, and C1 (0.4 μg/(kg·h) rate), groups A2, B2, and C2 (0.6 μg/(kg·h) rate), and groups A3, B3, and C3 (0.8 μg/(kg·h) rate) according to the dose used, with 55 cases in each group. Intraoperative anesthesia and postoperative adverse reactions were compared among the 9 groups. RESULTS the similarity between the Tri-training algorithm optimized by Naive Bayes (NB) classification algorithm and the actual classification (93.49%) was clearly higher than that by decision tree (DT) and K-nearest neighbor (kNN) classification algorithm (76.21%, 74.31%); heart rate (HR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) values decreased obviously after Dex used in groups B1, C1, B2, C2, B3, and C3 (P <0.05), but did not change significantly in groups A1, A2, and A3 (P >0.05); the proportion of patients with satisfactory Ramsay score in group A3 was distinctly superior than that in groups A1, A2, B1, B2, B3, C1, C2, and C3 (P <0.05); the incidence of adverse reactions in group A3 was significantly inferior than that in groups A1, A2, B1, B2, B3, C1, C2, and C3 (P <0.05). CONCLUSION the optimization effect of NB classification algorithm was the best, and the injection of Dex at the injection rate of 0.8 μg/(kg·h) before induction of anesthesia could apparently improve the fluctuation of HR, SBP, and DBP during perioperative period, and effectively reduce the occurrence of adverse reactions in patients, with better sedative effect on patients.
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Affiliation(s)
- Jing Xie
- Department of Anesthesiology, Xingtai People's Hospital, Xingtai, Hebei, China
| | - Shiqiang Feng
- Department of Anesthesiology, Xingtai People's Hospital, Xingtai, Hebei, China
| | - Zhenhua Qu
- Department of Anesthesiology, Xingtai People's Hospital, Xingtai, Hebei, China
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19
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Ramírez-del Real T, Martínez-García M, Márquez MF, López-Trejo L, Gutiérrez-Esparza G, Hernández-Lemus E. Individual Factors Associated With COVID-19 Infection: A Machine Learning Study. Front Public Health 2022; 10:912099. [PMID: 35844896 PMCID: PMC9279686 DOI: 10.3389/fpubh.2022.912099] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/04/2022] [Accepted: 05/24/2022] [Indexed: 11/13/2022] Open
Abstract
The fast, exponential increase of COVID-19 infections and their catastrophic effects on patients' health have required the development of tools that support health systems in the quick and efficient diagnosis and prognosis of this disease. In this context, the present study aims to identify the potential factors associated with COVID-19 infections, applying machine learning techniques, particularly random forest, chi-squared, xgboost, and rpart for feature selection; ROSE and SMOTE were used as resampling methods due to the existence of class imbalance. Similarly, machine and deep learning algorithms such as support vector machines, C4.5, random forest, rpart, and deep neural networks were explored during the train/test phase to select the best prediction model. The dataset used in this study contains clinical data, anthropometric measurements, and other health parameters related to smoking habits, alcohol consumption, quality of sleep, physical activity, and health status during confinement due to the pandemic associated with COVID-19. The results showed that the XGBoost model got the best features associated with COVID-19 infection, and random forest approximated the best predictive model with a balanced accuracy of 90.41% using SMOTE as a resampling technique. The model with the best performance provides a tool to help prevent contracting SARS-CoV-2 since the variables with the highest risk factor are detected, and some of them are, to a certain extent controllable.
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Affiliation(s)
- Tania Ramírez-del Real
- Cátedras Conacyt, National Council on Science and Technology, Mexico City, Mexico
- Center for Research in Geospatial Information Sciences, Mexico City, Mexico
| | - Mireya Martínez-García
- Clinical Research Division, National Institute of Cardiology “Ignacio Chávez”, Mexico City, Mexico
| | - Manlio F. Márquez
- Clinical Research Division, National Institute of Cardiology “Ignacio Chávez”, Mexico City, Mexico
| | - Laura López-Trejo
- Institute for Security and Social Services of State Workers, Mexico City, Mexico
| | - Guadalupe Gutiérrez-Esparza
- Cátedras Conacyt, National Council on Science and Technology, Mexico City, Mexico
- Clinical Research Division, National Institute of Cardiology “Ignacio Chávez”, Mexico City, Mexico
| | - Enrique Hernández-Lemus
- Computational Genomics Division, National Institute of Genomic Medicine, Mexico City, Mexico
- Center for Complexity Sciences, Universidad Nacional Autónoma de México, Mexico City, Mexico
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20
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Classifying the Mortality of People with Underlying Health Conditions Affected by COVID-19 Using Machine Learning Techniques. APPLIED COMPUTATIONAL INTELLIGENCE AND SOFT COMPUTING 2022. [DOI: 10.1155/2022/3783058] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022] Open
Abstract
The COVID-19 pandemic has greatly affected populations worldwide and has posed a significant challenge to medical systems. With the constant increase in the number of severe COVID-19 infections, an essential area of research has been directed towards predicting the mortality rate of these patients, in order to make informed medical decisions about the necessary healthcare priorities. Although a large amount of research has attempted to predict the mortality rate of COVID-19 patients, the association between the mortality rate of COVID-19 patients and their underlying health conditions has been given significantly less attention. Meanwhile, patients with underlying conditions often face a worse COVID-19 prognosis. Therefore, the goal of this study was to classify the mortality rate of patients diagnosed with COVID-19, who also suffer from underlying health conditions or comorbidities. To achieve our goal, we applied machine learning (ML) models on a new publicly available dataset, not investigated by any existing literature. The dataset provides detailed information on 582 COVID-19 patients and facilitates a robust forecasting model of the mortality rate. The dataset was analysed using seven ML classifiers, namely, Bagging, J48, logistic regression (LR), random forest (RF), support vector machine (SVM), naïve Bayes (NB), and threshold selector. A comparative analysis was performed across the seven ML techniques, and their performance was assessed based on evaluation parameters including classification accuracy, true-positive rate, and false-positive rate. The best performance was demonstrated by the Bagging algorithm with an accuracy of 83.55% when using all the dataset features. The findings are intended to assist researchers and physicians in the early identification of at-risk COVID-19 patients and to make the appropriate intensive care decisions.
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Tomasiuk R, Dabrowski J, Smykiewicz J, Wiacek M. Predictors of COVID-19 Hospital Treatment Outcome. Int J Gen Med 2022; 14:10247-10256. [PMID: 35221712 PMCID: PMC8866999 DOI: 10.2147/ijgm.s334544] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/22/2021] [Accepted: 10/20/2021] [Indexed: 12/14/2022] Open
Abstract
Background There are more than 228,394,572 confirmed cases and 4,690,186 confirmed deaths caused by COVID-19 worldwide. The magnitude of the COOVID-19 pandemic has stimulated research on the treatment and diagnosis of COVID-19 patients. Objective In this report, a battery of specific parameters was used to develop a model that allows prediction of the outcome of the COVID-19 treatment. These parameters are C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6. Methods The study was carried out on a sample of N = 49 survivors (22 men, 27 women) and 83 deceased patients (62 men, 21 women). The distribution of means and differences in means of the parameters studied between survivors and deceased patients were evaluated using the bootstrap method. Results A mathematical model that allows for the prediction of hospitalization outcome was obtained using the Naive Bayes model. The results demonstrated a statistically significant difference between survivors and deceased patients in all parameters studied. A mathematical model employing a battery of parameters provided a 97% precision in predicting the outcome of hospitalization. Conclusion This study showed that the cross-correlation of survivability with absolute levels of C-reactive protein, procalcitonin, fibrinogen, D-dimers, immature granulocytes, and interleukin-6 could be used successfully in the hospital setting as a diagnostic tool.
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Affiliation(s)
- Ryszard Tomasiuk
- Department of Medicine, Faculty of Medical and Health Sciences, The University of Technology and Humanities, Radom, Poland
| | - Jan Dabrowski
- Department of Pharmacology, National Medicines Institute, Warsaw, Poland
| | - Jolanta Smykiewicz
- Central Medical Diagnostic Laboratory, Dr. Tytus Chałubiński Specialist Hospital in Radom, Radom, Poland
| | - Magdalena Wiacek
- Department of Physiotherapy, Faculty of Medical and Health Sciences, The University of Technology and Humanities, Radom, Poland
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22
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Primary Factors Influencing the Decision to Vaccinate against COVID-19 in the United States: A Pre-Vaccine Analysis. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:ijerph19031026. [PMID: 35162050 PMCID: PMC8834206 DOI: 10.3390/ijerph19031026] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/15/2021] [Revised: 01/09/2022] [Accepted: 01/11/2022] [Indexed: 02/01/2023]
Abstract
Because vaccine hesitancy is a dynamic trait, it is critical to identify and compare the contributing factors at the different stages of a pandemic. The prediction of vaccine decision making and the interpretation of the analytical relationships among variables that encompass public perceptions and attitudes towards the COVID-19 pandemic have been extensively limited to the studies conducted after the administration of the first FDA-approved vaccine in December of 2020. In order to fill the gap in the literature, we used six predictive models and identified the most important factors, via Gini importance measures, that contribute to the prediction of COVID-19 vaccine acceptors and refusers using a nationwide survey that was administered in November 2020, before the widespread use of COVID-19 vaccines. Concerns about (re)contracting COVID-19 and opinions regarding mandatory face covering were identified as the most important predictors of vaccine decision making. By investigating the vaccine acceptors and refusers before the introduction of COVID-19 vaccines, we can help public health officials design and deliver individually tailored and dynamic vaccination programs that can increase the overall vaccine uptake.
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Bayesian Framework for Multi-Wave COVID-19 Epidemic Analysis Using Empirical Vaccination Data. MATHEMATICS 2021. [DOI: 10.3390/math10010021] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 12/16/2022]
Abstract
The COVID-19 pandemic has highlighted the necessity of advanced modeling inference using the limited data of daily cases. Tracking a long-term epidemic trajectory requires explanatory modeling with more complexities than the one with short-time forecasts, especially for the highly vaccinated scenario in the latest phase. With this work, we propose a novel modeling framework that combines an epidemiological model with Bayesian inference to perform an explanatory analysis on the spreading of COVID-19 in Israel. The Bayesian inference is implemented on a modified SEIR compartmental model supplemented by real-time vaccination data and piecewise transmission and infectious rates determined by change points. We illustrate the fitted multi-wave trajectory in Israel with the checkpoints of major changes in publicly announced interventions or critical social events. The result of our modeling framework partly reflects the impact of different stages of mitigation strategies as well as the vaccination effectiveness, and provides forecasts of near future scenarios.
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Application of intelligence-based computational techniques for classification and early differential diagnosis of COVID-19 disease. DATA SCIENCE AND MANAGEMENT 2021. [PMCID: PMC8654459 DOI: 10.1016/j.dsm.2021.12.001] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Indexed: 12/24/2022]
Abstract
Clinical methods are used for diagnosing COVID-19 infected patients, but reports posit that, several people who were initially tested positive of COVID-19, and who had some underlying diseases, turned out having negative results after further tests. Therefore, the performance of clinical methods is not always guaranteed. Moreover, chest X-ray image data of COVID-19 infected patients are mostly used in the computational models for COVID-19 diagnosis, while the use of common symptoms, such as fever, cough, fatigue, muscle aches, headache, etc. in computational models is not yet reported. In this study, we employed seven classification algorithms to empirically test and verify their efficacy when applied to diagnose COVID-19 using the aforementioned symptoms. We experimented with Logistic Regression (LR), Support Vector Machine (SVM), Naïve Byes (NB), Decision Tree (DT), Multilayer Perceptron (MLP), Fuzzy Cognitive Map (FCM) and Deep Neural Network (DNN) algorithms. The techniques were subjected to random undersampling and oversampling. Our results showed that with class imbalance, MLP and DNN outperform others. However, without class imbalance, MLP, FCM and DNN outperform others with the use of random undersampling, but DNN has the best performance by utilizing random oversampling. This study identified MLP, FCM and DNN as better classifiers over LR, NB, DT and SVM, so that healthcare software system developers can adopt them to develop intelligence-based expert systems which both medical personnel and patients can use for differential diagnosis of COVID-19 based on the aforementioned symptoms. However, the test of performance must not be limited to the traditional performance metrics.
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AlJame M, Imtiaz A, Ahmad I, Mohammed A. Deep forest model for diagnosing COVID-19 from routine blood tests. Sci Rep 2021; 11:16682. [PMID: 34404838 PMCID: PMC8371014 DOI: 10.1038/s41598-021-95957-w] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/27/2021] [Accepted: 08/03/2021] [Indexed: 02/07/2023] Open
Abstract
The Coronavirus Disease 2019 (COVID-19) global pandemic has threatened the lives of people worldwide and posed considerable challenges. Early and accurate screening of infected people is vital for combating the disease. To help with the limited quantity of swab tests, we propose a machine learning prediction model to accurately diagnose COVID-19 from clinical and/or routine laboratory data. The model exploits a new ensemble-based method called the deep forest (DF), where multiple classifiers in multiple layers are used to encourage diversity and improve performance. The cascade level employs the layer-by-layer processing and is constructed from three different classifiers: extra trees, XGBoost, and LightGBM. The prediction model was trained and evaluated on two publicly available datasets. Experimental results show that the proposed DF model has an accuracy of 99.5%, sensitivity of 95.28%, and specificity of 99.96%. These performance metrics are comparable to other well-established machine learning techniques, and hence DF model can serve as a fast screening tool for COVID-19 patients at places where testing is scarce.
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Affiliation(s)
- Maryam AlJame
- Department of Computer Engineering, Kuwait University, Kuwait City, Kuwait.
| | | | - Imtiaz Ahmad
- Department of Computer Engineering, Kuwait University, Kuwait City, Kuwait
| | - Ameer Mohammed
- Department of Computer Engineering, Kuwait University, Kuwait City, Kuwait
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Surianarayanan C, Chelliah PR. Leveraging Artificial Intelligence (AI) Capabilities for COVID-19 Containment. NEW GENERATION COMPUTING 2021; 39:717-741. [PMID: 34131359 PMCID: PMC8191724 DOI: 10.1007/s00354-021-00128-0] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 01/20/2021] [Accepted: 06/05/2021] [Indexed: 05/15/2023]
Abstract
The Coronavirus disease (COVID-19) is an infectious disease caused by the newly discovered Severe Acute Respiratory Syndrome Coronavirus two (SARS-CoV-2). Most of the people do not have the acquired immunity to fight this virus. There is no specific treatment or medicine to cure the disease. The effects of this disease appear to vary from individual to individual, right from mild cough, fever to respiratory disease. It also leads to mortality in many people. As the virus has a very rapid transmission rate, the entire world is in distress. The control and prevention of this disease has evolved as an urgent and critical issue to be addressed through technological solutions. The Healthcare industry therefore needs support from the domain of artificial intelligence (AI). AI has the inherent capability of imitating the human brain and assisting in decision-making support by automatically learning from input data. It can process huge amounts of data quickly without getting tiresome and making errors. AI technologies and tools significantly relieve the burden of healthcare professionals. In this paper, we review the critical role of AI in responding to different research challenges around the COVID-19 crisis. A sample implementation of a powerful probabilistic machine learning (ML) algorithm for assessment of risk levels of individuals is incorporated in this paper. Other pertinent application areas such as surveillance of people and hotspots, mortality prediction, diagnosis, prognostic assistance, drug repurposing and discovery of protein structure, and vaccine are presented. The paper also describes various challenges that are associated with the implementation of AI-based tools and solutions for practical use.
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Affiliation(s)
- Chellammal Surianarayanan
- Government Arts and Science College (Formerly Bharathidasan University Constituent Arts and Science College), Affiliated to Bharathidasan University, Tiruchirappalli, Tamilnadu India
| | - Pethuru Raj Chelliah
- Site Reliability Engineering Division, Reliance Jio Platforms Ltd, Bangalore, India
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Abiodun EO, Alabdulatif A, Abiodun OI, Alawida M, Alabdulatif A, Alkhawaldeh RS. A systematic review of emerging feature selection optimization methods for optimal text classification: the present state and prospective opportunities. Neural Comput Appl 2021; 33:15091-15118. [PMID: 34404964 PMCID: PMC8361413 DOI: 10.1007/s00521-021-06406-8] [Citation(s) in RCA: 22] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/07/2021] [Accepted: 07/31/2021] [Indexed: 02/07/2023]
Abstract
Specialized data preparation techniques, ranging from data cleaning, outlier detection, missing value imputation, feature selection (FS), amongst others, are procedures required to get the most out of data and, consequently, get the optimal performance of predictive models for classification tasks. FS is a vital and indispensable technique that enables the model to perform faster, eliminate noisy data, remove redundancy, reduce overfitting, improve precision and increase generalization on testing data. While conventional FS techniques have been leveraged for classification tasks in the past few decades, they fail to optimally reduce the high dimensionality of the feature space of texts, thus breeding inefficient predictive models. Emerging technologies such as the metaheuristics and hyper-heuristics optimization methods provide a new paradigm for FS due to their efficiency in improving the accuracy of classification, computational demands, storage, as well as functioning seamlessly in solving complex optimization problems with less time. However, little details are known on best practices for case-to-case usage of emerging FS methods. The literature continues to be engulfed with clear and unclear findings in leveraging effective methods, which, if not performed accurately, alters precision, real-world-use feasibility, and the predictive model's overall performance. This paper reviews the present state of FS with respect to metaheuristics and hyper-heuristic methods. Through a systematic literature review of over 200 articles, we set out the most recent findings and trends to enlighten analysts, practitioners and researchers in the field of data analytics seeking clarity in understanding and implementing effective FS optimization methods for improved text classification tasks.
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Affiliation(s)
- Esther Omolara Abiodun
- School of Computer Sciences, Universiti Sains Malaysia, George Town, Malaysia ,Department of Computer Sciences, University of Abuja, Abuja, Nigeria
| | - Abdulatif Alabdulatif
- Department of Computer Science, College of Computer, Qassim University, Buraydah, Saudi Arabia
| | - Oludare Isaac Abiodun
- School of Computer Sciences, Universiti Sains Malaysia, George Town, Malaysia ,Department of Computer Sciences, University of Abuja, Abuja, Nigeria
| | - Moatsum Alawida
- School of Computer Sciences, Universiti Sains Malaysia, George Town, Malaysia ,Department of Computer Sciences, Abu Dhabi University, Abu Dhabi, UAE
| | - Abdullah Alabdulatif
- Computer Department, College of Sciences and Arts, Qassim University, P.O. Box 53, Al-Rass, Saudi Arabia
| | - Rami S. Alkhawaldeh
- Department of Computer Information Systems, The University of Jordan, Aqaba, 77110 Jordan
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