Sleep-associated movement disorders and the risk of cardiovascular disease: A systematic review and meta-analysis

Table 1 Characteristics of the eligible studies included in the meta-analysis

Ref.	Year	Country	Study type	Total	Source of patients	CVD-OR (95%CI)	CAD-OR (95%CI)
Hanly et al[10]	1996	Canada	Cohort	32	PLMS	8.73 (0.94-81.49)	-
Ulfberg et al[11]	2001	Sweden	Case-control	4000	RLS	2.50 (1.40-4.30)	-
Ohayon et al[12]	2002	5 European countries	Cross-sectional	18980	PLMS/RLS	1.47 (1.12-1.81)	-
Winkelman et al[13]	2006	United States	Cohort	2821	RLS	2.07 (1.31-3.27)
Elwood et al[14]	2006	United Kingdom	Cohort	1871	RLS	1.38 (1.06-1.81)	1.24 (0.89-1.74)
Winkelman et al[15]	2008	United States	Cross-sectional	3433	RLS	2.07 (1.43-3.00)	2.05 (1.38-3.04)
Walters et al[16]	2010	United States	Cohort	267	RLS	2.46 (0.97-6.28)	-
Koo et al[17]	2011	United States	Cohort	2911	PLMS	1.28 (1.08-1.51)	1.23 (1.01-1.50)
Li et al[18]	2012	United States	Cohort	70977	RLS	1.46 (0.97-2.18)	1.46 (0.97-2.18)
Winter et al[19]	2012	United States	Cohort	48938	RLS	1.06 (0.90-1.26)	-
Lindner et al[20]	2012	Hungary	Cohort	150	PLMS	1.85 (0.46-7.51)	1.15 (0.35-3.81)
Mirza et al[21]	2013	United States	Case-control	584	PLMS	1.62 (1.14-2.30)	-
Szentkirályi et al[22]	2013	German	Cohort	4308	RLS	0.94 (0.42-2.10)	0.53 (0.12-2.27)

RLS: Restless legs syndrome; PLMS: Periodic limb movements during sleep; CVD: Cardiovascular disease; CAD: Coronary artery disease.