Prognostic significance of post percutaneous coronary intervention thrombocytopenia

Table 1 An overview of the studies whereby post-percutaneous coronary intervention thrombocytopenia was differently defined and analysed as an outcome variable

Ref.	Number of thrombocytopenic patients n (%)	Definition of thrombocytopenia	Mortality rate1	Hemorrhagic outcomes1	Composite Ischemic outcomes1
Berkowitz et al[10]	81/2099 (3.9)	Nadir PLT count < 100 × 109/L	12.1% vs 1.1% at 1 mo	48.7% vs 9.5% at 1 mo	NSC
McClure et al[8]	633/10948 (7.0)	Nadir PLT count < 100 × 109/L or delta PLT > 50%	7.4% vs 3.3% at 1 mo	75.8% vs 27.8% at 1 mo	30% vs 14.1% at 1 mo
Eikelboom et al[3]	87/10141 (1)	Nadir PLT count < 100 × 109/L	11.50% at 6 mo	8% vs 1.4% at 6 mo	33.3% vs 30.8%2 at 6 mo3
Merlini et al[4]	99/4809 (2.9)	Nadir PLT count < 100 × 109/L or delta PLT ≥ 25%	2.0% vs 0.4% at 1 mo	5.1% vs 0.7%	12.2% vs 6.6% at 1 mo
Nikolsky et al[9]	50/2082 (2.5)	Nadir PLT count < 100 × 109/L	10% vs 3.9% at 12 mo	10% vs 2.7%	26.1% vs 17.4% at 12 mo
Shenoy et al[32]	41/1302 (3.1)	Nadir PLT count < 100 × 109/L or delta PLT > 50%	10% vs 2% at 6 mo	37% vs 3%	39% vs 15% at 6 mo
Wang et al[6]	4697/36182 (13)	Nadir PLT count < 150 × 109/L and/or delta PLT > 50%	6.9% vs 2.6% in hospital stay	26.7% vs 10%	NC
De Labriolle et al[11]	1644/10146 (16.95)	Delta PLT ≥ 25%	11% vs 4.2% at 12 mo	21% vs 2.6%	22.9% vs 16.01% at 12 mo
Caixeta et al[7]	740/10836 (6.8)	Nadir PLT count < 150 × 109/L	6.5% vs 3.4% at 12 mo	14.0% vs 4.3%	22.8% vs 15.1% at 12 mo
Kiviniemi et al[35]	46/929 (9.7)	Nadir PLT count < 100 × 109/L or delta PLT > 50%	12% vs 11%2 at 12 mo	23% vs 22%2 at 12 mo	24% vs 19%2 at 12 mo

¹Thrombocytopenic vs non thrombocytopenic patients;

²Not statistically different;

³There was a significant difference at 7 d only. Inclusion and exclusion criteria were different in all studies. NC: Not considered; NSC: Not statistically considered; PCI: Percutaneous coronary intervention; PLT: Platelets.