Systematic Reviews
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Jun 28, 2021; 9(3): 297-308
Published online Jun 28, 2021. doi: 10.13105/wjma.v9.i3.297
Glycated haemoglobin reduction and fixed ratio combinations of analogue basal insulin and glucagon-like peptide-1 receptor agonists: A systematic review
Poobalan Naidoo, Celia Bouharati, Virendra Rambiritch, Sumanth Karamchand, Barbara A Tafuto, Rory F Leisegang
Poobalan Naidoo, Department of Nephrology, Inkosi Albert Luthuli Central Hospital, Durban 4092, KwaZulu-Natal, South Africa
Celia Bouharati, Department of Medical Research, Independent Researcher, Paris 75000, France
Virendra Rambiritch, Department of Pharmacology, University of KwaZulu-Natal, Durban 3629, KwaZulu-Natal, South Africa
Sumanth Karamchand, Department of Internal Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town 7600, South Africa
Barbara A Tafuto, Department of Health Informatics, Rutgers University, Piscataway, NJ 08854, United States
Rory F Leisegang, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala 75236, Sweden
Author contributions: Naidoo P and Tafuto BA conceived the manuscript; Leisegang RF, Rambiritch V, Karamchand S and Bouharati C reviewed all drafts and added critical comment and content; All authors read the final manuscript, consented to submission and take full responsibility for the content.
Conflict-of-interest statement: No conflict of interest.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Poobalan Naidoo, BPharm, MBChB, MSc, Academic Research, Doctor, Department of Nephrology, Inkosi Albert Luthuli Central Hospital, 800 Vusi Mzimela Rd, Durban 4092, KwaZulu-Natal, South Africa. poobalan1naidoo@yahoo.com
Received: March 27, 2021
Peer-review started: March 27, 2021
First decision: May 12, 2021
Revised: June 5, 2021
Accepted: July 2, 2021
Article in press: July 2, 2021
Published online: June 28, 2021
Core Tip

Core Tip: This systematic review investigates the effect of fixed ratio combinations of analogue insulin and glucagon like peptide-1 agonists on reduction of glycated haemoglobin. This systematic review helps fulfil a data gap that will help clinicians decide on comparative efficacy of members of the fixed ratio combination class.