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Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Jun 28, 2021; 9(3): 257-276
Published online Jun 28, 2021. doi: 10.13105/wjma.v9.i3.257
Immune response to Helicobacter pylori infection and gastric cancer development
Breno Bittencourt de Brito, Fabian Fellipe Bueno Lemos, Caroline da Mota Carneiro, Andressa Santos Viana, Nilo Manoel Pereira Vieira Barreto, Gabriela Alves de Souza Assis, Barbara Dicarlo Costa Braga, Maria Luísa Cordeiro Santos, Filipe Antônio França da Silva, Hanna Santos Marques, Natália Oliveira e Silva, Fabrício Freire de Melo
Breno Bittencourt de Brito, Fabian Fellipe Bueno Lemos, Caroline da Mota Carneiro, Andressa Santos Viana, Nilo Manoel Pereira Vieira Barreto, Gabriela Alves de Souza Assis, Barbara Dicarlo Costa Braga, Maria Luísa Cordeiro Santos, Filipe Antônio França da Silva, Natália Oliveira e Silva, Fabrício Freire de Melo, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Vitória da Conquista 45029-094, Bahia, Brazil
Hanna Santos Marques, Campus Vitória da Conquista, Universidade Estadual do Sudoeste da Bahia, Vitória da Conquista 45031900, Bahia, Brazil
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabrício Freire de Melo, MSc, PhD, Postdoc, Professor, Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Rua Hormindo Barros, 58, Quadra 17, Lote 58, Bairro Candeias, Vitória da Conquista 45029-094, Bahia, Brazil. freiremelo@yahoo.com.br
Received: February 23, 2021
Peer-review started: February 23, 2021
First decision: April 6, 2021
Revised: April 24, 2021
Accepted: June 15, 2021
Article in press: June 15, 2021
Published online: June 28, 2021
Core Tip

Core Tip: Gastric cancer affects more than 1 million people yearly, and Helicobacter pylori (H. pylori) infection is the main risk factor for that malignancy. Moreover, the immune response against the infection seems to play a pivotal role in gastric carcinogenesis. This article provides a broad and updated overview on the main aspects regarding H. pylori infection, immune response, and gastric cancer development.