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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Meta-Anal. Apr 28, 2021; 9(2): 101-107
Published online Apr 28, 2021. doi: 10.13105/wjma.v9.i2.101
Published online Apr 28, 2021. doi: 10.13105/wjma.v9.i2.101
Effect of resistance exercise on insulin sensitivity of skeletal muscle
Bo Wang, Department of Internal Medicine, Yantaishan Hospital, Yantai 264001, Shandong Province, China
Xu Luo, Rong-Rong Li, Ya-Na Li, Department of Pathophysiology, School of Basic Medicine, Binzhou Medical University, Yantai 264003, Shandong Province, China
Yu-Chi Zhao, Department of Osteoarthropathy, Yantaishan Hospital, Yantai 264001, Shandong Province, China
Author contributions: Zhao YC conceived the idea for the manuscript; Luo X, Li RR, and Li YN contributed to the writing of the manuscript; Wang B reviewed the literature and drafted the manuscript.
Supported by National Natural Science Foundation of China Youth Project , No. 31702024 ; Shandong Province Higher Educational Science and Technology Plan Project , No. J17KA258 .
Conflict-of-interest statement: None.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yu-Chi Zhao, MD, Chief Doctor, Department of Osteoarthropathy, Yantaishan Hospital, No. 91 Jiefang Road, Zhifu District, Yantai 264001, Shandong Province, China. zhaoyuchizyc@163.com
Received: January 27, 2021
Peer-review started: January 27, 2021
First decision: February 25, 2021
Revised: March 10, 2021
Accepted: April 23, 2021
Article in press: April 23, 2021
Published online: April 28, 2021
Peer-review started: January 27, 2021
First decision: February 25, 2021
Revised: March 10, 2021
Accepted: April 23, 2021
Article in press: April 23, 2021
Published online: April 28, 2021
Core Tip
Core Tip: Both muscle contraction and hypoxia can mobilize the transfer of glucose transporter-4. Resistance exercises (RTs) can significantly increase limb muscle content and body fat content and significantly reduce blood glucose and glycosylated hemoglobin levels in patients with type 2 diabetes mellitus (T2DM). Lipid accumulation in skeletal muscle cells potentially leads to insulin resistance (IR). RT or acute RT can lower intracellular lipid accumulation in muscle, which helps reduce peripheral IR. It is suggested that the RT-induced microvascular blood flow increase helps improve glucose metabolism in patients with skeletal muscle IR and T2DM.